Manifold epigenetics: A conceptual model that guides engineering strategies to improve whole-body regenerative health.
Manifold epigenetics: A conceptual model that guides engineering strategies to improve whole-body regenerative health.
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DOI：
10.3389/fcell.2023.1122422
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发表时间：
2023
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
尽管再生医学取得了可喜的进展，但迫切需要改进治疗方法。例如，延缓老龄化和提高健康寿命是迫在眉睫的社会挑战。我们识别生物线索的能力以及细胞和器官之间的通信是增强再生健康和改善患者护理的关键。表观遗传学代表了组织再生的主要生物学机制之一，因此可以被视为一种系统（全身）控制。然而，表观遗传调控如何协同导致生物记忆在全身水平的发展仍不清楚。在这里，我们回顾了不断发展的表观遗传学定义，并确定了缺失的环节。然后，我们提出了我们的流形表观遗传模型（MEMo）作为一个概念框架来解释表观遗传记忆是如何产生的，并讨论了可以应用哪些策略来操纵全身记忆。总之，我们为改善再生健康的新工程方法的发展提供了一个概念性的路线图。
Despite the promising advances in regenerative medicine, there is a critical need for improved therapies. For example, delaying aging and improving healthspan is an imminent societal challenge. Our ability to identify biological cues as well as communications between cells and organs are keys to enhance regenerative health and improve patient care. Epigenetics represents one of the major biological mechanisms involving in tissue regeneration, and therefore can be viewed as a systemic (body-wide) control. However, how epigenetic regulations concertedly lead to the development of biological memories at the whole-body level remains unclear. Here, we review the evolving definitions of epigenetics and identify missing links. We then propose our Manifold Epigenetic Model (MEMo) as a conceptual framework to explain how epigenetic memory arises and discuss what strategies can be applied to manipulate the body-wide memory. In summary we provide a conceptual roadmap for the development of new engineering approaches to improve regenerative health.
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影响因子：
29
作者：
Brandhorst S;Choi IY;Wei M;Cheng CW;Sedrakyan S;Navarrete G;Dubeau L;Yap LP;Park R;Vinciguerra M;Di Biase S;Mirzaei H;Mirisola MG;Childress P;Ji L;Groshen S;Penna F;Odetti P;Perin L;Conti PS;Ikeno Y;Kennedy BK;Cohen P;Morgan TE;Dorff TB;Longo VD
通讯作者：
Longo VD
影响因子：
10.5
作者：
Berger, Shelley L.;Kouzarides, Tony;Shilatifard, Ali
通讯作者：
Shilatifard, Ali
影响因子：
64.8
作者：
Conboy, IM;Conboy, MJ;Rando, TA
通讯作者：
Rando, TA
影响因子：
17.1
作者：
Fischbach MA;Bluestone JA;Lim WA
通讯作者：
Lim WA
DOI：
10.1126/science.1191078
发表时间：
2010-10-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bonasio R;Tu S;Reinberg D
通讯作者：
Reinberg D