Classification of crystallization outcomes using deep convolutional neural networks.

Classification of crystallization outcomes using deep convolutional neural networks.
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DOI:
10.1371/journal.pone.0198883
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发表时间:
2018
期刊:
影响因子:
3.7
通讯作者:
Wilson J
Wilson J
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Bruno AE;Charbonneau P;Newman J;Snell EH;So DR;Vanhoucke V;Watkins CJ;Williams S;Wilson J

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结晶结果的机器识别(MARCO)计划已经从各种来源和设置中收集了大约50万张大分子结晶实验的注释图像。在这里,最先进的机器学习算法在此数据集的不同部分上进行训练和测试。我们发现,超过94%的测试图像可以被正确标记,无论其实验起源。由于晶体识别是高密度筛选和结晶实验系统分析的关键,因此这种方法为工业和基础研究应用打开了大门。
The Machine Recognition of Crystallization Outcomes (MARCO) initiative has assembled roughly half a million annotated images of macromolecular crystallization experiments from various sources and setups. Here, state-of-the-art machine learning algorithms are trained and tested on different parts of this data set. We find that more than 94% of the test images can be correctly labeled, irrespective of their experimental origin. Because crystal recognition is key to high-density screening and the systematic analysis of crystallization experiments, this approach opens the door to both industrial and fundamental research applications.
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期刊: Journal of structural and functional genomics
影响因子: --
作者:
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期刊: ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
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发表时间: 2016-07-29
影响因子: 9.9
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