tRNA-Derived Small RNAs and Their Potential Roles in Cardiac Hypertrophy.
tRNA-Derived Small RNAs and Their Potential Roles in Cardiac Hypertrophy.
复制标题
DOI：
10.3389/fphar.2020.572941
复制
发表时间：
2020
影响因子：
5.6
通讯作者：
Wang DZ
中科院分区：
文献类型：
--
作者：
Cao J;Cowan DB;Wang DZ
转运rna （trna）是一种表达丰富的小非编码rna，长期以来被认为是蛋白质翻译机制的重要组成部分。tRNA衍生的小rna (tsRNAs)，包括tRNA一半（tiRNAs）和tRNA片段（trf），是意外发现的，并涉及多种重要的生物学功能，如细胞增殖、细胞分化和细胞凋亡。在机制上，tsRNAs调节mRNA的不稳定和翻译，以及逆转录元件逆转录和转录后过程。新出现的证据表明，tsRNAs在心脏中表达，其表达可由病理性应激诱导，如肥大。有趣的是，心脏病理生理条件，如氧化应激、衰老和代谢紊乱可以被视为tsRNA生物发生的诱导剂，这进一步强调了tsRNA在这些条件中的潜在参与。研究tsRNAs在心脏中的分子和生物学功能及其在心血管疾病中的作用的热情越来越高。预计这类新的非编码小rna将为理解疾病机制提供新的视角，并可能为治疗心血管疾病提供新的治疗靶点。
Transfer RNAs (tRNAs) are abundantly expressed, small non-coding RNAs that have long been recognized as essential components of the protein translation machinery. The tRNA-derived small RNAs (tsRNAs), including tRNA halves (tiRNAs), and tRNA fragments (tRFs), were unexpectedly discovered and have been implicated in a variety of important biological functions such as cell proliferation, cell differentiation, and apoptosis. Mechanistically, tsRNAs regulate mRNA destabilization and translation, as well as retro-element reverse transcriptional and post-transcriptional processes. Emerging evidence has shown that tsRNAs are expressed in the heart, and their expression can be induced by pathological stress, such as hypertrophy. Interestingly, cardiac pathophysiological conditions, such as oxidative stress, aging, and metabolic disorders can be viewed as inducers of tsRNA biogenesis, which further highlights the potential involvement of tsRNAs in these conditions. There is increasing enthusiasm for investigating the molecular and biological functions of tsRNAs in the heart and their role in cardiovascular disease. It is anticipated that this new class of small non-coding RNAs will offer new perspectives in understanding disease mechanisms and may provide new therapeutic targets to treat cardiovascular disease.
登录
查看更多内容
影响因子：
5.3
作者：
Chu W;Wan L;Zhao D;Qu X;Cai F;Huo R;Wang N;Zhu J;Zhang C;Zheng F;Cai R;Dong D;Lu Y;Yang B
通讯作者：
Yang B
影响因子：
14.9
作者：
Chan PP;Lowe TM
通讯作者：
Lowe TM
DOI：
10.1242/dev.167833
发表时间：
2018-11-09
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Boroviak T;Stirparo GG;Dietmann S;Hernando-Herraez I;Mohammed H;Reik W;Smith A;Sasaki E;Nichols J;Bertone P
通讯作者：
Bertone P
DOI：
10.1006/bbrc.1995.2172
发表时间：
1995-08-15
影响因子：
3.1
作者：
CASALI, C;SANTORELLI, FM;DIMAURO, S
通讯作者：
DIMAURO, S
影响因子：
10.5
作者：
Babiarz, Joshua E.;Ruby, J. Graham;Blelloch, Robert
通讯作者：
Blelloch, Robert