Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems.
Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems.
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DOI：
10.1186/alzrt164
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Golde TE
中科院分区：
文献类型：
--
作者：
Galasko D;Golde TE
血液中可以检测到全身产生的物质，血液是临床测试中最常见的生物液体。长期以来，人们一直在血液中寻找阿尔茨海默病(AD)的生物标记物，但没有一项成为既定或有效的诊断测试。阿尔茨海默病研究与治疗的配套综述将回顾特定类型的生物标记物或应用；在本综述中，我们一般涵盖与AD血液生物标记物研究相关的关键概念。概述了难以在血液中检测特定大脑疾病的标记物的原因；这些原因给血液生物标记物的发现和开发带来了概念上的挑战。血液测试在AD中的应用不仅仅是筛查和诊断测试；其他潜在的应用还包括风险评估、预测和评估治疗目标的参与度、毒性和结果。讨论了围绕这些不同用途可能存在的机会和问题。生物标记物的发现、检测、分析开发和质量控制、样本收集、处理和储存，以及临床研究的设计和分析都需要在发现和翻译的每个步骤中实施系统的方法，以确定可解释和有用的生物标记物。
Substances produced throughout the body are detectable in the blood, which is the most common biological fluid used in clinical testing. Biomarkers for Alzheimer's disease (AD) have long been sought in the blood, but none has become an established or validated diagnostic test. Companion reviews in Alzheimer's Research & Therapy will review specific types of biomarkers or applications; in this overview, we cover key concepts related to AD blood biomarker studies in general. Reasons for the difficulty of detecting markers of a brain-specific disorder, such as AD, in the blood are outlined; these pose conceptual challenges for blood biomarker discovery and development. Applications of blood tests in AD go beyond screening and diagnostic testing; other potential uses are risk assessment, prognostication, and evaluation of treatment target engagement, toxicity, and outcome. Opportunities and questions that may surround these different uses are discussed. A systematic approach to biomarker discovery, detection, assay development and quality control, sample collection, handling and storage, and design and analysis of clinical studies needs to be implemented at every step of discovery and translation to identify an interpretable and useful biomarker.
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影响因子：
3.7
作者：
O'Bryant SE;Xiao G;Barber R;Huebinger R;Wilhelmsen K;Edwards M;Graff-Radford N;Doody R;Diaz-Arrastia R;Texas Alzheimer's Research & Care Consortium;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
--
作者：
Koyama, Alain;Okereke, Olivia I.;Yang, Ting;Blacker, Deborah;Selkoe, Dennis J.;Grodstein, Francine
通讯作者：
Grodstein, Francine
DOI：
10.1186/alzrt121
发表时间：
2012-05-23
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Moore BD;Chakrabarty P;Levites Y;Kukar TL;Baine AM;Moroni T;Ladd TB;Das P;Dickson DW;Golde TE
通讯作者：
Golde TE
影响因子：
--
作者：
Soares, Holly D.;Potter, William Z.;Pickering, Eve;Kuhn, Max;Immermann, Frederick W.;Shera, David M.;Ferm, Mats;Dean, Robert A.;Simon, Adam J.;Swenson, Frank;Siuciak, Judith A.;Kaplow, June;Thambisetty, Madhav;Zagouras, Panayiotis;Koroshetz, Walter J.;Wan, Hong I.;Trojanowski, John Q.;Shaw, Leslie M.
通讯作者：
Shaw, Leslie M.
影响因子：
2.5
作者：
Mehta, PD;Pirttila, T;Mehta, SP
通讯作者：
Mehta, SP