Redox signaling in cardiovascular pathophysiology: A focus on hydrogen peroxide and vascular smooth muscle cells.
Redox signaling in cardiovascular pathophysiology: A focus on hydrogen peroxide and vascular smooth muscle cells.
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DOI：
10.1016/j.redox.2016.08.015
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发表时间：
2016-10
期刊：
影响因子：
11.4
通讯作者：
Chen, Yabing
中科院分区：
文献类型：
--
作者：
Byon, Chang Hyun;Heath, Jack M.;Chen, Yabing
氧化应激是指细胞内活性氧（ROS）水平过高，在心血管疾病的发病机制中起重要作用。氧化应激除了对动脉粥样硬化和糖尿病血管病变等血管病变的发生和发展有重要影响外，还调节生理信号过程。过氧化氢（H2O2）作为一种参与细胞内信号传导的细胞代谢产生的细胞渗透性ROS，对心血管病理生理具有重要影响。在病理条件下，氧化酶活性增加和/或抗氧化系统受损导致ROS的产生不受控制。在促氧化环境下，血管平滑肌细胞（VSMC）发生表型变化，导致血管功能障碍的发展，如血管炎症和钙化。氧化应激诱导心血管疾病的机制研究正在进行中。现就H2O2在VSMC生理病理信号调控中的作用作一综述。
Oxidative stress represents excessive intracellular levels of reactive oxygen species (ROS), which plays a major role in the pathogenesis of cardiovascular disease. Besides having a critical impact on the development and progression of vascular pathologies including atherosclerosis and diabetic vasculopathy, oxidative stress also regulates physiological signaling processes. As a cell permeable ROS generated by cellular metabolism involved in intracellular signaling, hydrogen peroxide (H2O2) exerts tremendous impact on cardiovascular pathophysiology. Under pathological conditions, increased oxidase activities and/or impaired antioxidant systems results in uncontrolled production of ROS. In a pro-oxidant environment, vascular smooth muscle cells (VSMC) undergo phenotypic changes which can lead to the development of vascular dysfunction such as vascular inflammation and calcification. Investigations are ongoing to elucidate the mechanisms for cardiovascular disorders induced by oxidative stress. This review mainly focuses on the role of H2O2 in regulating physiological and pathological signals in VSMC.
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