Removal of acetaldehyde from saliva by a slow‐release buccal tablet of L‐cysteine
Removal of acetaldehyde from saliva by a slow‐release buccal tablet of L‐cysteine
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L-半胱氨酸缓释颊片去除唾液中的乙醛
DOI：
10.1002/ijc.1620
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发表时间：
2002
影响因子：
6.4
通讯作者：
M. Salaspuro
中科院分区：
文献类型：
--
作者：
V. Salaspuro;J. Hietala;P. Kaihovaara;Liisa Pihlajarinne;M. Marvola;M. Salaspuro
高酒精摄入量是上胃肠道癌症的一个独立危险因素。越来越多的证据表明，乙醇的第一代谢物乙醛可能与乙醇相关的致癌作用有关。特别是在ALDH2缺乏基因的亚洲重度饮酒者中，即无法去除乙醛的基因，消化道癌症的风险显着增加。口腔微生物、粘膜细胞或唾液腺对乙醇产生的局部乙醛可能是唾液中的致癌物。我们研究的目的是研究是否有可能将唾液中的致癌乙醛与L -半胱氨酸结合，L -半胱氨酸从一种特殊的口腔片剂中缓慢释放。9名健康男性志愿者参加了我们的研究，每个受试者都作为自己的对照。在上唇处固定安慰剂或含L -半胱氨酸片。随后，志愿者摄入0.8 g/kg体重10% （v/v）乙醇，每隔20分钟采集唾液样本，持续320分钟。用顶空气相色谱法分析唾液乙醛和乙醇水平。L -半胱氨酸片与安慰剂相比，唾液中乙醛浓度的平均降低率为59% （CL95% 43%, 76%）。L -半胱氨酸和安慰剂片的曲线下面积（AUC0-320min）分别为54.3±11 μM × hr和162±34.2 μM × hr (mean±SEM) （p = 0.003）。酒精摄入后，高达三分之二的致癌物乙醛可以通过缓释的口腔L -半胱氨酸药物配方从唾液中去除。因此，颊半胱氨酸片剂可能用于预防上消化道癌症，特别是在高危人群中。©2001 Wiley‐Liss, Inc。
High alcohol intake is an independent risk factor for upper gastrointestinal (GI)‐tract cancers. There is increasing evidence that acetaldehyde, the first metabolite of ethanol, might be responsible for ethanol‐associated carcinogenesis. Especially among Asian heavy drinkers with the ALDH2‐deficiency gene, i.e., a genetic inability to remove acetaldehyde, the risk of digestive tract cancers is markedly increased. Local acetaldehyde production from ethanol either by oral microbes, mucosal cells or salivary glands is a plausible carcinogenic agent in the saliva. The aim of our study was to examine whether is it possible to bind carcinogenic acetaldehyde from saliva with L‐cysteine, which is slowly released from a special buccal tablet. Nine healthy male volunteers took part in our study, and each subject served as his own control. A placebo or L‐cysteine‐containing tablet was fastened under the upper lip. Thereafter the volunteers ingested 0.8 g/kg of body weight of 10% (v/v) ethanol, and saliva samples were collected at 20 min intervals for 320 min. Salivary acetaldehyde and ethanol levels were analysed by headspace gas chromatography. The mean reduction of acetaldehyde concentration of the saliva with the L‐cysteine tablet compared to placebo was 59% (CL95% 43%, 76%). Area under the curve (AUC0–320min) with the L‐cysteine and placebo tablet were 54.3 ± 11 μM × hr and 162 ± 34.2 μM × hr (mean ± SEM), respectively (p = 0.003). After alcohol intake, up to two‐thirds of carcinogenic acetaldehyde can be removed from saliva with a slow‐releasing buccal L‐cysteine drug formulation. Thus, a buccal cysteine tablet could potentially be used to prevent upper GI‐tract cancers, especially among high‐risk individuals. © 2001 Wiley‐Liss, Inc.
长期饮酒大鼠肝脏中蛋白质-乙醛加合物的检测。
DOI：
10.1172/jci113362
发表时间：
1988
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Lin,RC;Smith,RS;Lumeng,L
通讯作者：
Lumeng,L