Differential Roles for Diploid and Polyploid Hepatocytes in Acute and Chronic Liver Injury.
Differential Roles for Diploid and Polyploid Hepatocytes in Acute and Chronic Liver Injury.
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DOI：
10.1055/s-0040-1719175
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发表时间：
2021-01
影响因子：
4.2
通讯作者：
Duncan AW
中科院分区：
文献类型：
--
作者：
Wilkinson PD;Duncan AW
肝细胞是肝脏的主要功能细胞，在体内平衡、再生和损伤中发挥重要作用。大多数哺乳动物的体细胞是二倍体，每个染色体都有一对，但也有一些多倍体细胞含有额外的染色体。肝细胞是最好描述的多倍体细胞之一，其中多倍体分别占人类和小鼠肝细胞群体的25%和90%以上。调节肝多倍体的细胞和分子机制已经被发现，近年来，二倍体和多倍体肝细胞已被证明执行专门的功能。二倍体肝细胞可加速切除诱导的肝再生，并可加速急性损伤后的代偿性再生。多倍体肝细胞保护肝脏免受肝细胞癌（HCC）的肿瘤引发，并促进对酪氨酸血症诱导的慢性损伤的适应。这篇综述介绍了倍性变化如何影响细胞活性，并提出了一个模型的上下文特异性功能的二倍体和多倍体肝细胞。
Hepatocytes are the primary functional cells of the liver that perform essential roles in homeostasis, regeneration and injury. Most mammalian somatic cells are diploid and contain pairs of each chromosome, but there are also polyploid cells containing additional sets of chromosomes. Hepatocytes are among the best described polyploid cells, with polyploids comprising more than 25% and 90% of the hepatocyte population in humans and mice, respectively. Cellular and molecular mechanisms that regulate hepatic polyploidy have been uncovered, and in recent years, diploid and polyploid hepatocytes have been shown to perform specialized functions. Diploid hepatocytes accelerate liver regeneration induced by resection and may accelerate compensatory regeneration after acute injury. Polyploid hepatocytes protect the liver from tumor initiation in hepatocellular carcinoma (HCC) and promote adaptation to tyrosinemia-induced chronic injury. This review describes how ploidy variations influence cellular activity and presents a model for context-specific functions for diploid and polyploid hepatocytes.
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影响因子：
29.4
作者：
El-Serag HB
通讯作者：
El-Serag HB
影响因子：
3.4
作者：
Austin LS;Kaushansky A;Kappe SH
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Kappe SH
影响因子：
30.8
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GROMPE, M;LINDSTEDT, S;FINEGOLD, M
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FINEGOLD, M
影响因子：
29.4
作者：
Duncan AW;Hanlon Newell AE;Smith L;Wilson EM;Olson SB;Thayer MJ;Strom SC;Grompe M
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影响因子：
13.6
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Gast CE;Silk AD;Zarour L;Riegler L;Burkhart JG;Gustafson KT;Parappilly MS;Roh-Johnson M;Goodman JR;Olson B;Schmidt M;Swain JR;Davies PS;Shasthri V;Iizuka S;Flynn P;Watson S;Korkola J;Courtneidge SA;Fischer JM;Jaboin J;Billingsley KG;Lopez CD;Burchard J;Gray J;Coussens LM;Sheppard BC;Wong MH
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Wong MH