Blood in saliva of patients with acquired immunodeficiency syndrome: Possible implication in sexual transmission of the disease
Blood in saliva of patients with acquired immunodeficiency syndrome: Possible implication in sexual transmission of the disease
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获得性免疫缺陷综合征患者唾液中的血液：可能与该疾病的性传播有关
DOI：
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发表时间：
1994
影响因子：
12.7
通讯作者：
R. Orlando
中科院分区：
文献类型：
--
作者：
M. Piazza;A. Chirianni;L. Picciotto;P. Cataldo;G. Borgia;R. Orlando
研究了抗人类免疫缺陷病毒 (HIV) 阳性受试者、高感染风险抗 HIV 阴性受试者和健康对照者唾液中血红蛋白的存在和浓度。 188 名受试者为抗 HIV 阳性静脉吸毒者 (IVDA)，22 名受试者为抗 HIV 阳性同性恋男性，23 名受试者为抗 HIV 阳性异性接触者，132 名受试者为抗 HIV 阴性 IVDA，35 名受试者为抗 HIV 阴性男性，154 名为健康对照。早上刷牙前收集两毫升唾液，测定血红蛋白的存在和浓度。根据血红蛋白，数据显示抗 HIV 阳性 IVDA 的出血倾向最高。该组在抗 HIV 阴性 IVDA 方面（P < 0.05）与健康对照（P < 0.01）相比，差异具有统计学意义。与健康对照相比，抗 HIV 阳性异性接触也是如此（P < 0.01）。我们的数据显示，所有高危人群，无论是抗 HIV 阳性还是抗 HIV 阴性，其血红蛋白浓度均高于对照组；这种差异仅在抗 HIV 阳性 IVDA 和对照之间达到统计学显着性（P < 0.01）。与 CD4+ 淋巴细胞 > 200/mm3 的受试者相比，CD4+ 淋巴细胞 < 200/mm3 的受试者的血红蛋白浓度显着高于 CD4+ 淋巴细胞 > 200/mm3 的受试者（P < 0.01），患有 AIDS 相关综合征的受试者（ARO/AIDS 与无症状/PGL 受试者相比，P < 0.01），以及患有口腔炎的受试者与无口腔炎的受试者相比（P < 0.05）。讨论了艾滋病，特别是 IVDA，可以在创伤性和重复性行为（例如热情接吻、插入口交等）中通过唾液传播感染。 © 1994 Wiiey‐Liss, Inc.。
The presence and concentration of haemoglobin in saliva of anti‐human immunodeficiency virus (HIV) positive subjects, anti‐HIV‐negative subjects at high risk of infection, and healthy controls were studied. One hundred eighty‐eight subjects were anti‐HIV‐positive intravenous drug abusers (IVDA), 22 were anti‐HIV‐positive homosexual men, 23 were anti‐HIV‐positive heterosexual contacts, 132 were anti‐HIV‐negative IVDA, 35 were anti‐HIV‐negative homosexual men, and 154 were healthy controls. Two milliliters of saliva was collected in the morning before brushing teeth, and the presence and the concentration of haemoglobin were determined. Based on hemoglobin, the data show that the anti‐HIV‐positive IVDA have the highest tendency to bleeding. The difference between this group with respect to anti‐HIV‐negative IVDA (P < 0.05) and compared with healthy controls (P < 0.01) is statistically significant. This is also true of anti‐HIV‐positive heterosexual contacts with respect to healthy controls (P < 0.01). Our data show that all at‐risk groups, both anti‐HIV positive and anti‐HIV negative, have higher haemoglobin concentration than the control group; this difference reaches statistical significance only between anti‐HIV‐positive IVDA and controls (P < 0.01). The concentration of haemoglobin is significantly higher in subjects with CD4+ lymphocytes < 200/mm3 compared to subjects with CD4+ lymphocytes > 200/mm3 (P < 0.01), in subjects with AIDS‐related complex (ARO/AIDS compared to asymptomatic/PGL subjects (P < 0.01), and in subjects with stomatitis compared to subjects without stomatitis (P < 0.05). The possibility that subjects with AIDS, particularly IVDA, could transmit infection through saliva in traumatic and repetitive sexual context (e.g., passionate kissing, insertive fellatio, etc.) is discussed. © 1994 Wiiey‐Liss, Inc.
患有艾滋病相关综合症的人和有艾滋病风险的健康男同性恋者唾液中的 HTLV-III。
DOI：
10.1126/science.6093247
发表时间：
1984
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Groopman,JE;Salahuddin,SZ;Sarngadharan,MG;Markham,PD;Gonda,M;Sliski,A;Gallo,RC
通讯作者：
Gallo,RC
影响因子：
158.5
作者：
HO, DD;MOUDGIL, T;ALAM, M
通讯作者：
ALAM, M