Pathological mechanism of chondrocytes and the surrounding environment during osteoarthritis of temporomandibular joint.
Pathological mechanism of chondrocytes and the surrounding environment during osteoarthritis of temporomandibular joint.
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DOI：
10.1111/jcmm.16514
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发表时间：
2021-06
影响因子：
5.3
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Li B;Guan G;Mei L;Jiao K;Li H
颞下颌关节骨关节炎是颞下颌关节常见的慢性退行性疾病。为了探讨其病因和病理机制，人们建立了多种动物模型和细胞模型来模拟颞下颌关节骨关节炎的病理过程。颞下颌关节骨关节炎的主要病理特征包括软骨细胞死亡、细胞外基质降解和软骨下骨改建。软骨细胞凋亡加速了软骨的破坏。然而，自噬对髁突软骨细胞具有保护作用。ECM的降解不仅改变软骨的性质，而且影响软骨细胞的表型。颞下颌关节骨关节炎早期软骨下骨的丢失在骨关节炎的发病中起着病因学作用。近年来，越来越多的证据表明，软骨细胞肥大和软骨内血管生成促进TMJ骨关节炎。肥大的软骨细胞分泌许多促进软骨退变的因子。这些软骨细胞可以进一步分化为成骨细胞和骨细胞，并加速软骨骨化。软骨内血管生成和神经发生被认为是颞下颌关节骨关节炎关节痛的重要诱因。软骨内成骨过程中的许多分子信号通路是导致TMJ骨关节炎的原因。TMJ骨关节炎的这些最新发现进一步增强了对这种疾病的理解，并有助于分子治疗的发展。本文综述了近年来对颞下颌关节骨关节炎发病机制的认识，重点阐述了软骨细胞肥大变性和软骨血管生成在其中的作用。
Temporomandibular joint (TMJ) osteoarthritis is a common chronic degenerative disease of the TMJ. In order to explore its aetiology and pathological mechanism, many animal models and cell models have been constructed to simulate the pathological process of TMJ osteoarthritis. The main pathological features of TMJ osteoarthritis include chondrocyte death, extracellular matrix (ECM) degradation and subchondral bone remodelling. Chondrocyte apoptosis accelerates the destruction of cartilage. However, autophagy has a protective effect on condylar chondrocytes. Degradation of ECM not only changes the properties of cartilage but also affects the phenotype of chondrocytes. The loss of subchondral bone in the early stages of TMJ osteoarthritis plays an aetiological role in the onset of osteoarthritis. In recent years, increasing evidence has suggested that chondrocyte hypertrophy and endochondral angiogenesis promote TMJ osteoarthritis. Hypertrophic chondrocytes secrete many factors that promote cartilage degeneration. These chondrocytes can further differentiate into osteoblasts and osteocytes and accelerate cartilage ossification. Intrachondral angiogenesis and neoneurogenesis are considered to be important triggers of arthralgia in TMJ osteoarthritis. Many molecular signalling pathways in endochondral osteogenesis are responsible for TMJ osteoarthritis. These latest discoveries in TMJ osteoarthritis have further enhanced the understanding of this disease and contributed to the development of molecular therapies. This paper summarizes recent cognition on the pathogenesis of TMJ osteoarthritis, focusing on the role of chondrocyte hypertrophy degeneration and cartilage angiogenesis.
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DOI：
10.1016/j.joms.2015.03.042
发表时间：
2015-09
期刊：
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
影响因子：
--
作者：
Henderson SE;Tudares MA;Tashman S;Almarza AJ
通讯作者：
Almarza AJ
HMGB1诱导人颞下颌关节穿孔盘细胞血管生成
影响因子：
5.3
作者：
Feng Y;Ke J;Cao P;Deng M;Li J;Cai H;Meng Q;Li Y;Long X
通讯作者：
Long X
影响因子：
12.7
作者：
Chen D;Shen J;Zhao W;Wang T;Han L;Hamilton JL;Im HJ
通讯作者：
Im HJ
影响因子：
3
作者：
Ge, Xianpeng;Shi, Ruirui;Ma, Xuchen
通讯作者：
Ma, Xuchen
影响因子：
4.6
作者：
Jiao K;Zeng G;Niu LN;Yang HX;Ren GT;Xu XY;Li FF;Tay FR;Wang MQ
通讯作者：
Wang MQ