Role of exosomal proteins in cancer diagnosis.
Role of exosomal proteins in cancer diagnosis.
复制标题
外泌体蛋白在癌症诊断中的作用。
DOI：
10.1186/s12943-017-0706-8
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发表时间：
2017-08-29
期刊：
影响因子：
37.3
通讯作者：
Chen D
中科院分区：
文献类型：
--
作者：
Li W;Li C;Zhou T;Liu X;Liu X;Li X;Chen D
外泌体正在成为一种新型的癌症生物标志物。外泌体是一种存在于各种体液中的由多种活细胞分泌的双层纳米囊泡。基于对它们的生物发生、细胞分泌和癌细胞特异性分子和遗传内容物的不断扩大但不完整的了解，外泌体被视为癌症进展和对治疗的反应的有前景的、临床相关的替代物。癌细胞来源或癌血浆来源的外泌体的初步蛋白质组学、遗传和功能分析证实了它们的独特特征。血浆中外来体的蛋白质或核酸谱的改变与包括癌症在内的许多疾病的病理过程相关。然而，以前关于外泌体在癌症诊断和治疗中的应用的研究主要集中在miRNA上。随着exosomal蛋白的快速大规模生产、纯化、提取和筛选技术的发展，exosomal蛋白在癌症早期诊断、监测和预后评估中的应用前景广阔。本文就近年来外来体蛋白在肿瘤诊断中的应用进展作一综述。
Exosomes are emerging as a new type of cancer biomarkers. Exosome is a bilayered nano-sized vesicle secreted by various living cells in all body fluids. Based on the expanding albeit incomplete knowledge of their biogenesis, secretion by cells and cancer cell-specific molecular and genetic contents, exosomes are viewed as promising, clinically-relevant surrogates of cancer progression and response to therapy. Preliminary proteomic, genetic and functional profiling of cancer cell-derived or cancer plasma-derived exosomes confirms their unique characteristics. Alterations in protein or nucleic acid profiles of exosomes in plasma correlate with pathological processes of many diseases including cancer. However, previous studies on exosome application in cancer diagnosis and treatment mainly focussed on miRNAs. With the development of rapid large-scale production, purification, extraction and screening of exosomal contents, exosomal protein application can be explored for early stage cancer diagnosis, monitoring and prognosis evaluation. Here, we summarized the recent developments in application of exosomal proteins for cancer diagnosis.
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影响因子：
64.5
作者：
Boelens MC;Wu TJ;Nabet BY;Xu B;Qiu Y;Yoon T;Azzam DJ;Twyman-Saint Victor C;Wiemann BZ;Ishwaran H;Ter Brugge PJ;Jonkers J;Slingerland J;Minn AJ
通讯作者：
Minn AJ
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3.7
作者：
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通讯作者：
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影响因子：
21.3
作者：
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影响因子：
5.5
作者：
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通讯作者：
Zitvogel, L
影响因子：
7
作者：
Chornoguz, Olesya;Grmai, Lydia;Ostrand-Rosenberg, Suzanne
通讯作者：
Ostrand-Rosenberg, Suzanne