The Potential Important Role of Mitochondrial Rieske Iron-Sulfur Protein as a Novel Therapeutic Target for Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease.
The Potential Important Role of Mitochondrial Rieske Iron-Sulfur Protein as a Novel Therapeutic Target for Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease.
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DOI：
10.3390/biomedicines10050957
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发表时间：
2022-04-21
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
慢性阻塞性肺疾病（COPD）是全球第三大死亡原因，通常是由于肺动脉高压（PH）。潜在的分子机制知之甚少，目前的药物既不特异也不总是有效。在这篇综述中，我们强调了最近的研究结果，改变线粒体生物能量学的作用，在PH在COPD。我们还讨论了由Rieske铁硫蛋白（RISP）介导的线粒体活性氧（ROS）产生的中心作用，并回顾了RISP依赖的DNA损伤和NF-κ B相关炎症信号的贡献。最后，详细讨论了线粒体RISP及其相关分子作为COPD PH治疗新靶点的潜在重要性。
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, which is often due to pulmonary hypertension (PH). The underlying molecular mechanisms are poorly understood, and current medications are neither specific nor always effective. In this review, we highlight the recent findings on the roles of altered mitochondrial bioenergetics in PH in COPD. We also discuss the central role of mitochondrial reactive oxygen species (ROS) generation mediated by Rieske iron–sulfur protein (RISP) and review the contributions of RISP-dependent DNA damage and NF-κB-associated inflammatory signaling. Finally, the potential importance of mitochondrial RISP and its associated molecules as novel therapeutic targets for PH in COPD are meticulously discussed.
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