Application of human amniotic epithelial cells in regenerative medicine: a systematic review.
Application of human amniotic epithelial cells in regenerative medicine: a systematic review.
复制标题
人羊膜上皮细胞在再生医学中的应用：系统评价
DOI：
10.1186/s13287-020-01951-w
复制
发表时间：
2020-10-15
影响因子：
7.5
通讯作者：
Lai D
中科院分区：
文献类型：
--
作者：
Zhang Q;Lai D
来源于胎盘组织的人羊膜上皮细胞（hAECs）在再生医学领域受到了广泛的关注。hAECs具有胚胎干细胞样的增殖和分化能力，以及成体干细胞样的免疫调节特性。与其他类型的干细胞相比，hAECs具有易于分离、数量丰富、避免伦理争议、非免疫原性和非致瘤性等特殊优势。在过去的二十年中，人们对haec治疗各种疾病的潜力进行了广泛的研究。越来越多的证据表明，hAEC移植通过不同的分子机制帮助修复和重建受损组织和器官的功能。本文系统综述了hAECs的生物学特性、治疗应用以及在治疗各种组织损伤和疾病方面的最新进展。使用PubMed、MEDLINE和谷歌Scholar综合检索2000 - 2020年发表的英文相关研究，描述hAECs在疾病和表型中的作用。根据研究内容，我们描述了hAEC的主要特征，包括诱导分化可塑性、归巢与分化、旁分泌功能和免疫调节特性。总结了临床研究现状，并对基于haec的移植治疗进行了展望。在这篇综述中，我们提供了对hAECs的治疗潜力的全面了解，包括它们在细胞替代治疗以及分泌细胞因子和外泌体生物治疗中的应用。此外，我们发现haec强大的免疫调节功能为其在免疫相关疾病治疗中的应用提供了更多的可能性。在未来，建立最佳的培养程序，实现精确和准确的治疗，并通过适当的预处理和/或生物材料增强治疗潜力将是进一步研究的新挑战。
Human amniotic epithelial cells (hAECs) derived from placental tissues have gained considerable attention in the field of regenerative medicine. hAECs possess embryonic stem cell-like proliferation and differentiation capabilities, and adult stem cell-like immunomodulatory properties. Compared with other types of stem cell, hAECs have special advantages, including easy isolation, plentiful numbers, the obviation of ethical debates, and non-immunogenic and non-tumorigenic properties. During the past two decades, the therapeutic potential of hAECs for treatment of various diseases has been extensively investigated. Accumulating evidence has demonstrated that hAEC transplantation helps to repair and rebuild the function of damaged tissues and organs by different molecular mechanisms. This systematic review focused on summarizing the biological characteristics of hAECs, therapeutic applications, and recent advances in treating various tissue injuries and disorders. Relevant studies published in English from 2000 to 2020 describing the role of hAECs in diseases and phenotypes were comprehensively sought out using PubMed, MEDLINE, and Google Scholar. According to the research content, we described the major hAEC characteristics, including induced differentiation plasticity, homing and differentiation, paracrine function, and immunomodulatory properties. We also summarized the current status of clinical research and discussed the prospects of hAEC-based transplantation therapies. In this review, we provide a comprehensive understanding of the therapeutic potential of hAECs, including their use for cell replacement therapy as well as secreted cytokine and exosome biotherapy. Moreover, we showed that the powerful immune-regulatory function of hAECs reveals even more possibilities for their application in the treatment of immune-related diseases. In the future, establishing the optimal culture procedure, achieving precise and accurate treatment, and enhancing the therapeutic potential by utilizing appropriate preconditioning and/or biomaterials would be new challenges for further investigation.
登录
查看更多内容
维生素C提高人羊膜上皮细胞对卵巢早衰疾病的治疗潜力
影响因子：
7.5
作者：
Hou, Shunyu;Ding, Chenyue;Li, Hong
通讯作者：
Li, Hong
影响因子：
2.8
作者：
Fatimah, Simat Siti;Tan, Geok Chin;Hayati, Abdul Rahman
通讯作者：
Hayati, Abdul Rahman
当在含有血清替代补充剂的培养基中培养时，人羊膜上皮细胞分化为表达生殖细胞特异性标记的细胞。
DOI：
10.1186/1477-7827-10-108
发表时间：
2012-12-14
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Evron A;Goldman S;Shalev E
通讯作者：
Shalev E
影响因子：
2.9
作者：
Baker, Elizabeth Kate;Malhotra, Atul;Wallace, Euan M.
通讯作者：
Wallace, Euan M.
影响因子：
1.6
作者：
Easley, Charles A.;Miki, Toshio;Schatten, Gerald P.
通讯作者：
Schatten, Gerald P.