The Evolving Roles of Cardiac Macrophages in Homeostasis, Regeneration, and Repair.
The Evolving Roles of Cardiac Macrophages in Homeostasis, Regeneration, and Repair.
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DOI：
10.3390/ijms22157923
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发表时间：
2021-07-25
影响因子：
5.6
通讯作者：
O'Meara CC
中科院分区：
文献类型：
--
作者：
Alvarez-Argote S;O'Meara CC
巨噬细胞最初被描述为通过清除干扰正常功能的病原体来维持组织稳态的吞噬免疫细胞。从历史上看，巨噬细胞被认为是终末分化的单核细胞来源的细胞，起源于造血，在炎症存在或在正常体内平衡的转换过程中浸润多个组织。然而，改进的细胞检测和命运定位策略已经阐明了组织巨噬细胞的各种谱系，它们可以来源于胚胎起源，独立于造血和单核细胞浸润。巨噬细胞在皮肤、肝脏和肺部等器官中的作用已经得到了很好的表征，其功能远远超出了单纯的吞噬和免疫作用。在心脏中，最近的研究已经开始通过命运定位和基因消耗研究来破译各种组织巨噬细胞群体的功能作用。其中一些研究已经阐明了心脏巨噬细胞在体内平衡中的新的和意想不到的作用，包括维持线粒体功能，促进心脏传导，冠状动脉发育和淋巴管生成等。此外，在心脏损伤后，心内巨噬细胞具有清除坏死、凋亡细胞和碎片、减少炎性单核细胞浸润、促进血管生成、改善炎症和剩余心肌肥厚等多种功能，总体上限制了损伤的扩展。本文综述了巨噬细胞在稳态、心脏再生、心脏损伤或应激后的起源、发展、特征和功能。
Macrophages were first described as phagocytic immune cells responsible for maintaining tissue homeostasis by the removal of pathogens that disturb normal function. Historically, macrophages have been viewed as terminally differentiated monocyte-derived cells that originated through hematopoiesis and infiltrated multiple tissues in the presence of inflammation or during turnover in normal homeostasis. However, improved cell detection and fate-mapping strategies have elucidated the various lineages of tissue-resident macrophages, which can derive from embryonic origins independent of hematopoiesis and monocyte infiltration. The role of resident macrophages in organs such as the skin, liver, and the lungs have been well characterized, revealing functions well beyond a pure phagocytic and immunological role. In the heart, recent research has begun to decipher the functional roles of various tissue-resident macrophage populations through fate mapping and genetic depletion studies. Several of these studies have elucidated the novel and unexpected roles of cardiac-resident macrophages in homeostasis, including maintaining mitochondrial function, facilitating cardiac conduction, coronary development, and lymphangiogenesis, among others. Additionally, following cardiac injury, cardiac-resident macrophages adopt diverse functions such as the clearance of necrotic and apoptotic cells and debris, a reduction in the inflammatory monocyte infiltration, promotion of angiogenesis, amelioration of inflammation, and hypertrophy in the remaining myocardium, overall limiting damage extension. The present review discusses the origin, development, characterization, and function of cardiac macrophages in homeostasis, cardiac regeneration, and after cardiac injury or stress.
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影响因子：
20.1
作者：
DeBerge M;Yeap XY;Dehn S;Zhang S;Grigoryeva L;Misener S;Procissi D;Zhou X;Lee DC;Muller WA;Luo X;Rothlin C;Tabas I;Thorp EB
通讯作者：
Thorp EB
影响因子：
6.4
作者：
Davies LC;Taylor PR
通讯作者：
Taylor PR
影响因子：
4
作者：
de Back DZ;Kostova EB;van Kraaij M;van den Berg TK;van Bruggen R
通讯作者：
van Bruggen R
影响因子：
24
作者：
Courties, Gabriel;Heidt, Timo;Sebas, Matthew;Iwamoto, Yoshiko;Jeon, Derrick;Truelove, Jessica;Tricot, Benoit;Wojtkiewicz, Greg;Dutta, Partha;Sager, Hendrik B.;Borodovsky, Anna;Novobrantseva, Tatiana;Klebanov, Boris;Fitzgerald, Kevin;Anderson, Daniel G.;Libby, Peter;Swirski, Filip K.;Weissleder, Ralph;Nahrendorf, Matthias
通讯作者：
Nahrendorf, Matthias
影响因子：
20.3
作者：
Dai, XM;Ryan, GR;Stanley, ER
通讯作者：
Stanley, ER