Bone Microenvironment and Osteosarcoma Metastasis.
Bone Microenvironment and Osteosarcoma Metastasis.
复制标题
骨微环境与骨肉瘤转移
DOI：
10.3390/ijms21196985
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发表时间：
2020-09-23
影响因子：
5.6
通讯作者：
Qian A
中科院分区：
文献类型：
--
作者：
Yang C;Tian Y;Zhao F;Chen Z;Su P;Li Y;Qian A
骨微环境是原发性和继发性肿瘤播种的理想肥沃土壤。骨肉瘤作为一种原发性骨肿瘤，其发生发展与骨微环境密切相关。尤其是骨肉瘤的转移是治疗的一大挑战，预后差。骨微环境与骨肉瘤转移的关系越来越受到重视。骨微环境中存在多种因素，如酸、缺氧、趋化因子等，它们通过多种信号通路影响骨肉瘤的发生发展。本文对这些调控因子在骨微环境中的作用及其传递途径进行了综述，试图为改善骨微环境抑制骨肉瘤转移提供线索。此外，分析骨微环境与骨肉瘤的相互作用，有助于我们深入了解骨肉瘤的发生发展。骨微环境中促进骨肉瘤转移的细胞和分子主角将加速骨肉瘤治疗新策略的探索。
The bone microenvironment is an ideal fertile soil for both primary and secondary tumors to seed. The occurrence and development of osteosarcoma, as a primary bone tumor, is closely related to the bone microenvironment. Especially, the metastasis of osteosarcoma is the remaining challenge of therapy and poor prognosis. Increasing evidence focuses on the relationship between the bone microenvironment and osteosarcoma metastasis. Many elements exist in the bone microenvironment, such as acids, hypoxia, and chemokines, which have been verified to affect the progression and malignance of osteosarcoma through various signaling pathways. We thoroughly summarized all these regulators in the bone microenvironment and the transmission cascades, accordingly, attempting to furnish hints for inhibiting osteosarcoma metastasis via the amelioration of the bone microenvironment. In addition, analysis of the cross-talk between the bone microenvironment and osteosarcoma will help us to deeply understand the development of osteosarcoma. The cellular and molecular protagonists presented in the bone microenvironment promoting osteosarcoma metastasis will accelerate the exploration of novel therapeutic strategies towards osteosarcoma.
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骨微环境：肿瘤生长的肥沃土壤。
影响因子：
4.3
作者：
Buenrostro D;Mulcrone PL;Owens P;Sterling JA
通讯作者：
Sterling JA
癌症相关的间充质基质通过NF-κB激活对肿瘤内酸中毒的响应，促成骨肉瘤细胞的干性。
影响因子：
6.4
作者：
Avnet S;Di Pompo G;Chano T;Errani C;Ibrahim-Hashim A;Gillies RJ;Donati DM;Baldini N
通讯作者：
Baldini N
影响因子：
3.4
作者：
Cheng G;Gao F;Sun X;Bi H;Zhu Y
通讯作者：
Zhu Y
影响因子：
8
作者：
Chan, L. H.;Wang, W.;Mak, K. K.
通讯作者：
Mak, K. K.
DOI：
10.1073/pnas.0805462105
发表时间：
2008-08-19
影响因子：
11.1
作者：
Berman, Seth D.;Calo, Eliezer;Lees, Jacqueline A.
通讯作者：
Lees, Jacqueline A.