Epidemiology of NSAID-induced gastropathy
Epidemiology of NSAID-induced gastropathy
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NSAID 诱发胃病的流行病学
DOI：
10.1007/bf02206654
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发表时间：
1991
影响因子：
3.4
通讯作者：
H. Zeidler
中科院分区：
文献类型：
--
作者：
H. Zeidler
虽然非甾体类抗炎药（NSAIDS）和胃肠道（GI）症状之间的关联已经知道了很多年，但这种不良反应的重要性一直存在争议。风湿病学家和全科医生认为NSAID是一种非常有价值的，通常耐受性良好的药物，用于关节炎和肌肉骨骼疾病的一线治疗。胃肠病学家和外科医生坚持认为，它们是胃肠道粘膜的危险刺激物，可能致命。这些相互矛盾的观点主要是基于个人经验，而不是基于对流行病学报告的仔细分析。因此，以下概述将简要讨论消化性溃疡疾病和NSAID引起的胃病的一些一般流行病学方面，然后描述人口和临床流行病学的最重要的数据和观察结果，最后指出未来研究的必要性以及新的观点。
Although the association between nonsteroidal antiinflammatory drugs (NSAIDS) and gastrointestinal (GI) symptoms has been known for many years, the importance of such adverse effects has been subject to debate. Rheumatologists and general practitioners see NSAIDs as an extremely valuable and generally well tolerated kind of drug for first line use in arthritis and musculoskeletal disorders. Gastroenterologists and surgeons insist that they are dangerous irritants of the gastrointestinal mucosa and potentially lethal. These conflicting positions are primarilly based on personal experiences rather than on careful analysis of epidemiological reports. Therefore, the following overview will briefly discuss some general epidemiological aspects of peptic ulcer disease and NSAID-induced gastropathy, then describe the most important data and observations of population and clinical epidemiology and finally point out the need for future research as well as new perspectives.
鼠 IgM 抗 IgG 单克隆自身抗体（类风湿因子）的可变区序列。
DOI：
10.1084/jem.165.4.970
发表时间：
1987
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Shlomchik,M;Nemazee,D;vanSnick,J;Weigert,M
通讯作者：
Weigert,M