Progress in childhood cancer: 50 years of research collaboration, a report from the Children's Oncology Group.
Progress in childhood cancer: 50 years of research collaboration, a report from the Children's Oncology Group.
复制标题
DOI：
10.1053/j.seminoncol.2008.07.008
复制
发表时间：
2008-10
影响因子：
4
通讯作者：
Children's Oncology Group
中科院分区：
文献类型：
--
作者：
O'Leary M;Krailo M;Anderson JR;Reaman GH;Children's Oncology Group
儿童肿瘤学小组(COG)最近庆祝了肿瘤学50年来儿科临床试验和合作研究的里程碑。我们的小组起源于四个遗留的儿科临床试验小组：儿童癌症小组、儿科肿瘤组、国家肾母细胞瘤研究小组和组间横纹肌肉瘤研究小组，这四个小组于2000年合并为COG。在过去的50年里，儿童癌症的存活率从10%上升到了近80%。急性淋巴细胞性白血病(ALL)的预后已经从6个月的中位生存期上升到85%的总治愈率。我们已经修改了大多数主要疾病的治疗方法，以最少的长期后遗症来诱导缓解。在这里，我们回顾了我们的进步，但也展望了下一个50年，它将产生更成功的治疗方法，这些治疗方法将根据特定的患者来翻译分子遗传学的工具。经验清楚地证明，我们对儿童癌症的诊断和治疗所知道的一切都是研究的结果，儿童癌症死亡率的历史大幅下降与合作小组的临床研究直接相关。
The Children's Oncology Group (COG) recently celebrated the milestone of 50 years of pediatric clinical trials and collaborative research in oncology. Our group had its origins in the four legacy pediatric clinical trials groups: the Children's Cancer Group, the Pediatric Oncology Group, the National Wilms' Tumor Study Group and the Intergroup Rhabdomyosarcoma Study Group which merged in 2000 to form the COG. Over the last 50 years, the survival rates for childhood cancer have risen from 10% to almost 80%. Outcome in Acute Lymphoblastic Leukemia (ALL) has gone from a six month median survival to an 85% overall cure rate. We have modified therapies in most major diseases to induce remission with the least amount of long term sequelae. Here we look back on our advances but also look forward to the next 50 years which will produce even more successful treatments that will be tailored to the specific patient translating the tools of molecular genetics. Experience has clearly proven that everything we know about the diagnosis and management of childhood cancer is a result of research and the dramatic historical decrease in mortality from childhood cancer is directly related to cooperative group clinical research.
登录
查看更多内容
影响因子：
45.3
作者：
BURGERT, EO;NESBIT, ME;GILULA, L
通讯作者：
GILULA, L
影响因子：
20.3
作者：
BURCHENAL, JH;MURPHY, ML;RHOADS, CP
通讯作者：
RHOADS, CP
DOI：
10.1016/s0360-3016(01)01709-6
发表时间：
2001-11-01
影响因子：
7
作者：
Donaldson, SS;Meza, J;Wharam, M
通讯作者：
Wharam, M
影响因子：
45.3
作者：
Green, DM;Breslow, NE;D'Angio, GJ
通讯作者：
D'Angio, GJ
影响因子：
158.5
作者：
DUFFNER, PK;HOROWITZ, ME;KUN, LE
通讯作者：
KUN, LE