Cross-Linked Fluorescent Supramolecular Nanoparticles as Finite Tattoo Pigments with Controllable Intradermal Retention Times.
Cross-Linked Fluorescent Supramolecular Nanoparticles as Finite Tattoo Pigments with Controllable Intradermal Retention Times.
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DOI：
10.1021/acsnano.6b06200
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发表时间：
2017-01-24
期刊：
影响因子：
17.1
通讯作者：
Tseng HR
中科院分区：
文献类型：
--
作者：
Choi JS;Zhu Y;Li H;Peyda P;Nguyen TT;Shen MY;Yang YM;Zhu J;Liu M;Lee MM;Sun SS;Yang Y;Yu HH;Chen K;Chuang GS;Tseng HR
纹身已被医学界用于精确划分解剖标志。这种做法对于鉴定非黑色素瘤皮肤癌（NMSC）的活检部位特别重要，因为间隔时间长（即，最长3个月）。可商购获得的纹身颜料具有若干问题，其包括引起不良的美容效果、被误认为是黑色素细胞病变、当不再需要时需要额外的去除程序以及潜在地诱导炎症反应。用于标记NMSC的皮肤活检部位的理想纹身颜料需要（i）在环境光下不可见，（ii）在选择性光源下荧光，（iii）有限的皮内保留时间（约10分钟）。3个月），和（iv）生物相容性。在此，我们引入交联的荧光超分子纳米颗粒（c-FSNPs）作为“有限纹身”颜料，具有优化的生物物理性质和皮内保留时间，以实现成功的体内有限纹身。荧光超分子纳米粒子通过超分子合成方法将荧光共轭聚合物聚[5-甲氧基-2-（3-磺基丙氧基）-1，4-亚苯基亚乙烯]（MPS-PPV）封装到核中。通过组合筛选方法获得具有优于游离MPS-PPV的荧光性质的上级FSNP。FSNP的共价交联导致微米尺寸的c-FSNP，其表现出尺寸依赖性的皮内滞留。1456 nm大小的c-FSNP显示出理想的皮内保留时间（约10分钟）。3个月）进行NMSC病变标记，如在体内纹身研究中观察到的。此外，c-FSNPs在纹身后诱导不可检测的炎症反应。我们相信c-FSNPs可以作为一种“有限的纹身”色素来标记潜在的恶性NMSC病变。
Tattooing has been utilized by the medical community for precisely demarcating anatomic landmarks. This practice is especially important for identifying biopsy sites of nonmelanoma skin cancer (NMSC) due to the long interval (i.e., up to 3 months) between the initial diagnostic biopsy and surgical treatment. Commercially available tattoo pigments possess several issues, which include causing poor cosmesis, being mistaken for a melanocytic lesion, requiring additional removal procedures when no longer desired, and potentially inducing inflammatory responses. The ideal tattoo pigment for labeling of skin biopsy sites for NMSC requires (i) invisibility under ambient light, (ii) fluorescence under a selective light source, (iii) a finite intradermal retention time (ca. 3 months), and (iv) biocompatibility. Herein, we introduce cross-linked fluorescent supra-molecular nanoparticles (c-FSNPs) as a “finite tattoo” pigment, with optimized photophysical properties and intradermal retention time to achieve successful in vivo finite tattooing. Fluorescent supramolecular nanoparticles encapsulate a fluorescent conjugated polymer, poly[5-methoxy-2-(3-sulfopropoxy)-1,4-phenylenevinylene] (MPS-PPV), into a core via a supramolecular synthetic approach. FSNPs which possess fluorescent properties superior to those of the free MPS-PPV are obtained through a combinatorial screening process. Covalent cross-linking of FSNPs results in micrometer-sized c-FSNPs, which exhibit a size-dependent intradermal retention. The 1456 nm sized c-FSNPs display an ideal intradermal retention time (ca. 3 months) for NMSC lesion labeling, as observed in an in vivo tattoo study. In addition, the c-FSNPs induce undetectable inflammatory responses after tattooing. We believe that the c-FSNPs can serve as a “finite tattoo” pigment to label potential malignant NMSC lesions.
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影响因子：
16.6
作者：
Liu, Yang;Wang, Hao;Kamei, Ken-ichiro;Yan, Ming;Chen, Kuan-Ju;Yuan, Qinghua;Shi, Linqi;Lu, Yunfeng;Tseng, Hsian-Rong
通讯作者：
Tseng, Hsian-Rong
影响因子：
14
作者：
Chen, Kuan-Ju;Wolahan, Stephanie M.;Wang, Hao;Hsu, Chao-Hsiung;Chang, Hsing-Wei;Durazo, Armando;Hwang, Lian-Pin;Garcia, Mitch A.;Jiang, Ziyue K.;Wu, Lily;Lin, Yung-Ya;Tseng, Hsian-Rong
通讯作者：
Tseng, Hsian-Rong
影响因子：
2.4
作者：
Campbell, Ross M.;Perlis, Clifford S.;Dufresne, Raymond G., Jr.
通讯作者：
Dufresne, Raymond G., Jr.
影响因子：
15
作者：
PETTER, RC;SALEK, JS;LIN, FT
通讯作者：
LIN, FT
影响因子：
6.4
作者：
Rao, Rajeswara M.;Liao, Chia-Wei;Sun, Shih-Sheng
通讯作者：
Sun, Shih-Sheng