Individual differences in prefrontal cortex function and the transition from drug use to drug dependence.
Individual differences in prefrontal cortex function and the transition from drug use to drug dependence.
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DOI：
10.1016/j.neubiorev.2010.05.002
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发表时间：
2010-11
影响因子：
8.2
通讯作者：
Koob, George F.
中科院分区：
文献类型：
--
作者：
George, Olivier;Koob, George F.
关键词：
几个神经心理学假说已经制定了解释过渡到成瘾，包括享乐别稳态，激励显着性和习惯的发展。成瘾的一个关键特征仍有待探索，这是在自我给药倾向、对药物相关线索的敏感性、戒断状态的严重程度和戒烟能力方面观察到的重要个体差异。在这篇综述中，我们认为，自我调节的概念，结合认知功能的模块化的概念，可能有助于理解的神经基础的个体差异的脆弱性药物和过渡到成瘾。这篇评论的论点是，药物成瘾涉及控制处理奖励、疼痛、压力、情绪、习惯和决策的关键认知模块的执行系统的不同子组件的故障。一个子假设是，不同的模式的药物成瘾和个人差异的过渡到成瘾可能出现的差异脆弱性在一个或多个子组件。
Several neuropsychological hypotheses have been formulated to explain the transition to addiction, including hedonic allostasis, incentive salience, and the development of habits. A key feature of addiction that remains to be explored is the important individual variability observed in the propensity to self-administer drugs, the sensitivity to drug-associated cues, the severity of the withdrawal state, and the ability to quit. In this review, we suggest that the concept of self-regulation, combined with the concept of modularity of cognitive function, may aid in the understanding of the neural basis of individual differences in the vulnerability to drugs and the transition to addiction. The thesis of this review is that drug addiction involves a failure of the different subcomponents of the executive systems controlling key cognitive modules that process reward, pain, stress, emotion, habits, and decision-making. A subhypothesis is that the different patterns of drug addiction and individual differences in the transition to addiction may emerge from differential vulnerability in one or more of the subcomponents.
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DOI：
10.1073/pnas.93.24.13468
发表时间：
1996-11-26
影响因子：
11.1
作者：
Baddeley, A
通讯作者：
Baddeley, A
影响因子：
56.9
作者：
BECHARA, A;TRANEL, D;DAMASIO, AR
通讯作者：
DAMASIO, AR
影响因子：
2.3
作者：
Anthony, James C.;Warner, Lynn A.;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.
影响因子：
2.3
作者：
Ben-Shahar, Osnat;Obara, Ilona;Ary, Alexis W.;Ma, Natalie;Mangiardi, Mario A.;Medina, Robert L.;Szumlinski, Karen K.
通讯作者：
Szumlinski, Karen K.
影响因子：
3.4
作者：
Barrot, M;Abrous, DN;Piazza, PV
通讯作者：
Piazza, PV