Clinical efficacy of endoscopic retrograde cholangiopancreatography in the treatment of acute biliary pancreatitis: a meta-analysis.
Clinical efficacy of endoscopic retrograde cholangiopancreatography in the treatment of acute biliary pancreatitis: a meta-analysis.
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DOI：
10.5114/wiitm.2022.119902
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发表时间：
2022-12
期刊：
影响因子：
--
通讯作者：
Zhao L
中科院分区：
文献类型：
--
作者：
Tang D;Gu J;Ao Y;Zhao L
急性胆源性胰腺炎(ABP)是一种由胆道疾病引起的急腹症，引起流出道梗阻、胰管高压和随后的胰腺自身消化。目的探讨经内窥镜逆行胰胆管造影术(ERCP)治疗急性胰腺炎的临床疗效。对PubMed/WOS/CNKI/Wanfang四个数据库进行全面的文献检索，选择2010-2022年间发表的ERCP治疗ABP的随机对照试验。然后从符合条件的研究中提取相关数据。随后，使用Stata 16.0统计软件进行Meta分析和敏感性分析。用贝格法创建的漏斗图来确定发表偏倚。ABP患者1639例，其中观察组(ERCP或ERCP+内窥镜括约肌切开术)823例，对照组(保守治疗)816例。观察组有效率高，并发症发生率低，术后腹痛缓解时间、肠道排气时间、血清淀粉酶恢复正常时间、住院天数均优于对照组(p<；0.05)。此外，观察组治疗后生化指标和炎症因子水平(TBIL/WBC/C反应蛋白/肿瘤坏死因子-α)均明显好于对照组(P<；0.05)。总的来说，ERCP治疗ABP可以缓解腹痛，加速肠道排气和血清淀粉酶恢复，并有效改善血清生化参数和炎症因子水平。
Acute biliary pancreatitis (ABP) is a type of acute abdomen caused by biliary tract diseases that trigger outflow obstruction, hypertension of the pancreatic duct, and subsequent pancreatic autodigestion. To investigate the clinical efficacy of endoscopic retrograde cholangiopancreatography (ERCP) in the treatment of ABP. A comprehensive literature search was performed on four databases (PubMed/WOS/CNKI/Wanfang) to select randomized controlled trials on ERCP for ABP published between 2010 and 2022. Relevant data were then extracted from the eligible studies. Subsequently, meta-analysis and sensitivity analysis were performed using Stata 16.0 statistical software. Publication bias was determined using funnel plots created by the Begg method. A total of 1639 patients with ABP were included, of whom 823 were in the observation (ERCP or ERCP + endoscopic sphincterotomy) group and 816 in the control (conservative treatment) group. The observation group demonstrated a higher response rate, lower incidence of complications, and superior postoperative abdominal pain relief time, time to intestinal exhaust, serum amylase recovery time and hospital stay than the control group (p < 0.05). In addition, biochemical parameters and inflammatory factor levels (Tbil/WBC/CRP/TNF-α) were significantly better after treatment in the observation group than in the control group (p < 0.05). Collectively, ERCP in the treatment of ABP was associated with relief of abdominal pain, accelerated intestinal exhaust and serum amylase recovery, and effective improvements in serum biochemical parameters and inflammatory factor levels.
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影响因子：
168.9
作者：
NEOPTOLEMOS, JP;LONDON, NJ;FOSSARD, DP
通讯作者：
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发表时间：
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作者：
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