Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.
Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.
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DOI：
10.1016/j.it.2006.12.007
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发表时间：
2007-02
影响因子：
16.8
通讯作者：
Vanhaesebroeck B
中科院分区：
文献类型：
--
作者：
Okkenhaug K;Ali K;Vanhaesebroeck B
The activation of antigen receptors triggers two important signalling pathways originating from phosphatidylinositol(4,5)-bisphosphate [PtdIns(4,5)P2]. The first is phospholipase Cγ (PLCγ)-mediated hydrolysis of PtdIns(4,5)P2, resulting in the activation of Ras, protein kinase C and Ca2+ flux. This culminates in profound alterations in gene expression and effector-cell responses, including secretory granule exocytosis and cytokine production. By contrast, phosphoinositide 3-kinases (PI3Ks) phosphorylate PtdIns(4,5)P2 to yield phosphatidylinositol(3,4,5)-trisphosphate, activating signalling pathways that overlap with PLCγ or are PI3K-specific. Pathways that are PI3K-specific include Akt-mediated inactivation of Foxo transcription factors and transcription-independent regulation of glucose uptake and metabolism. The p110δ isoform of PI3K is the main source of PI3K activity following antigen recognition by B cells, T cells and mast cells. Here, we review the roles of p110δ in regulating antigen-dependent responses in these cell types.
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影响因子：
7.8
作者：
Astoul, E;Watton, S;Cantrell, D
通讯作者：
Cantrell, D
DOI：
10.1084/jem.20042020
发表时间：
2005-01-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
影响因子：
30.5
作者：
Costello, PS;Gallagher, M;Cantrell, DA
通讯作者：
Cantrell, DA
影响因子：
64.8
作者：
Ali, K;Bilancio, A;Vanhaesebroeck, B
通讯作者：
Vanhaesebroeck, B
影响因子：
20.3
作者：
Doughty, Cheryl A.;Bleiman, Blair F.;Chiles, Thomas C.
通讯作者：
Chiles, Thomas C.