Noninvasive, low-noise, fast imaging of blood volume and deoxygenation changes in muscles using light-emitting diode continuous-wave imager
Noninvasive, low-noise, fast imaging of blood volume and deoxygenation changes in muscles using light-emitting diode continuous-wave imager
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使用发光二极管连续波成像仪对肌肉中的血量和脱氧变化进行无创、低噪声、快速成像
DOI：
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
B. Chance
中科院分区：
文献类型：
--
作者：
Yuanqing Lin;G. Lech;S. Nioka;X. Intes;B. Chance
本文重点讨论优化三波长发光二极管 (LED) 近红外连续波 (cw) 成像仪的信噪比 (SNR) 及其在体内肌肉代谢测量中的应用。对于肌肉的生理血液浓度，导出并计算散粒噪声限制SNR为2×104。针对散粒噪声限制的信噪比性能和快速成像，我们利用采样和保持电路来降低高频噪声。这些电路还被设计为并行集成，当探头放置在肌肉模型上时，可以实现2×103的信噪比和2 Hz的成像采集率。噪声对应于 2×10−4 光密度误差，这表明体外分辨率为 15. 4 nM 血量和 46.8 nM 脱氧变化。采用 256 级 48 dB 数字增益控制电路来扩大成像仪的动态范围。我们利用袖带缺血作为活体模型演示并报告其结果。该仪器...
This article focuses on optimizing the signal to noise ratio (SNR) of a three-wavelength light-emitting diode (LED) near-infrared continuous-wave (cw) imager and its application to in vivo muscle metabolism measurement. The shot-noise limited SNR is derived and calculated to be 2×104 for the physiological blood concentrations of muscle. Aiming at shot-noise limited SNR performance and fast imaging, we utilize sample and hold circuits to reduce high-frequency noise. These circuits have also been designed to be parallel integrating, through which SNR of 2×103 and 2 Hz imaging acquisition rate have been achieved when the probe is placed on a muscle model. The noise corresponds to 2×10−4 optical density error, which suggests an in vitro resolution of 15. 4 nM blood volume and 46.8 nM deoxygenation changes. A 48 dB digital gain control circuit with 256 steps is employed to enlarge the dynamic range of the imager. We utilize cuff ischemia as a living model demonstration and its results are reported. The instrum...
影响因子：
4.8
作者：
Cerussi, AE;Berger, AJ;Tromberg, BJ
通讯作者：
Tromberg, BJ
DOI：
10.1073/pnas.91.11.4887
发表时间：
1994-05-24
影响因子：
11.1
作者：
BOAS, DA;OLEARY, MA;YODH, AG
通讯作者：
YODH, AG
高山滑雪期间血红蛋白/肌红蛋白氧饱和度降低。
影响因子：
4.1
作者：
Szmedra,L;Im,J;Nioka,S;Chance,B;Rundell,KW
通讯作者：
Rundell,KW