Aberrant Energy Metabolism in Alzheimer's Disease.
Aberrant Energy Metabolism in Alzheimer's Disease.
复制标题
DOI：
10.2478/jtim-2022-0024
复制
发表时间：
2022-09
影响因子：
4.9
通讯作者：
Zhu, Xiaolei
中科院分区：
文献类型：
--
作者：
Yu, Linjie;Jin, Jiali;Xu, Yun;Zhu, Xiaolei
为了维持对大脑的能量供应，通过线粒体和细胞质中葡萄糖的氧化磷酸化和有氧糖酵解产生称为三磷酸腺苷（ATP）的直接能量来源。脑葡萄糖代谢在许多神经退行性疾病中降低，包括阿尔茨海默病（AD），其中它以进行性和区域特异性的方式在症状前出现。在AD中能量代谢失调之后，许多细胞修复/再生过程被激活以保存细胞活力所需的能量。糖代谢在AD的病理过程中起重要作用，与三羧酸循环、2型糖尿病和胰岛素抵抗密切相关。神经元中的葡萄糖摄取来自内皮细胞、星形胶质细胞和小胶质细胞。神经中枢葡萄糖的损害也损害AD中的能量转运系统。肠道微生物群对于调节胃肠道和大脑之间的双向通信是必要的。肠道菌群可能通过调节免疫系统和维持肠道屏障的完整性来影响AD的过程。此外，一些治疗策略在不同阶段的AD治疗中显示出有希望的治疗效果，包括使用抗糖尿病药物，挽救线粒体功能障碍，以及表观遗传和饮食干预。本文综述了AD能量代谢改变的机制，并为AD的治疗提供了潜在的治疗策略。
To maintain energy supply to the brain, a direct energy source called adenosine triphosphate (ATP) is produced by oxidative phosphorylation and aerobic glycolysis of glucose in the mitochondria and cytoplasm. Brain glucose metabolism is reduced in many neurodegenerative diseases, including Alzheimer’s disease (AD), where it appears presymptomatically in a progressive and region-specific manner. Following dysregulation of energy metabolism in AD, many cellular repair/regenerative processes are activated to conserve the energy required for cell viability. Glucose metabolism plays an important role in the pathology of AD and is closely associated with the tricarboxylic acid cycle, type 2 diabetes mellitus, and insulin resistance. The glucose intake in neurons is from endothelial cells, astrocytes, and microglia. Damage to neurocentric glucose also damages the energy transport systems in AD. Gut microbiota is necessary to modulate bidirectional communication between the gastrointestinal tract and brain. Gut microbiota may influence the process of AD by regulating the immune system and maintaining the integrity of the intestinal barrier. Furthermore, some therapeutic strategies have shown promising therapeutic effects in the treatment of AD at different stages, including the use of antidiabetic drugs, rescuing mitochondrial dysfunction, and epigenetic and dietary intervention. This review discusses the underlying mechanisms of alterations in energy metabolism in AD and provides potential therapeutic strategies in the treatment of AD.
登录
查看更多内容
GLUT4 动员支持活跃突触的能量需求。
影响因子：
16.2
作者：
Ashrafi G;Wu Z;Farrell RJ;Ryan TA
通讯作者：
Ryan TA
影响因子：
15.1
作者：
Ali T;Rehman SU;Khan A;Badshah H;Abid NB;Kim MW;Jo MH;Chung SS;Lee HG;Rutten BPF;Kim MO
通讯作者：
Kim MO
影响因子：
3.9
作者：
Briston T;Hicks AR
通讯作者：
Hicks AR
影响因子：
4.8
作者：
Akbari E;Asemi Z;Daneshvar Kakhaki R;Bahmani F;Kouchaki E;Tamtaji OR;Hamidi GA;Salami M
通讯作者：
Salami M
影响因子：
5.3
作者：
Abramov, AY;Canevari, L;Duchen, MR
通讯作者：
Duchen, MR