Biaxial response of passive human cerebral arteries.
Biaxial response of passive human cerebral arteries.
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DOI：
10.1007/s10439-008-9578-9
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发表时间：
2008-12
影响因子：
3.8
通讯作者：
Manley, Geoffrey T.
中科院分区：
文献类型：
--
作者：
Monson, Kenneth L.;Barbaro, Nicholas M.;Manley, Geoffrey T.
关键词：
脑循环对脑组织的健康和维持至关重要，但损伤和疾病可能导致血管功能障碍。脑血管机械反应的表征是更全面了解这些血管损伤机制和疾病发展的重要一步，为改善预防和治疗铺平了道路。我们最近报道了一个大系列的单轴测试新鲜人脑血管，但这些血管的多轴行为还没有以前的描述。从接受手术的患者的颞叶表面获得12条动脉，并在拉伸至失效之前在典型生理条件下进行轴向拉伸和压力的各种组合。轴向和周向响应进行了比较，并测得的数据拟合到一个四参数，真菌型超弹性本构模型。动脉的行为是非线性和各向异性的，在轴向方向上的变形阻力比周围的圆周。加压容器的轴向失效试验结果导致应力-拉伸响应与以前报道的未加压试样的数据相比有一个小的变化。这些结果进一步明确了脑动脉的双轴反应，并为更严格地研究脑损伤机制和脑血管病的发展提供了所需的数据。
The cerebral circulation is fundamental to the health and maintenance of brain tissue, but injury and disease may result in dysfunction of the vessels. Characterization of cerebral vessel mechanical response is an important step toward a more complete understanding of injury mechanisms and disease development in these vessels, paving the way for improved prevention and treatment. We recently reported a large series of uniaxial tests on fresh human cerebral vessels, but the multi-axial behavior of these vessels has not been previously described. Twelve arteries were obtained from the surface of the temporal lobe of patients undergoing surgery and were subjected to various combinations of axial stretch and pressure around typical physiological conditions before being stretched to failure. Axial and circumferential responses were compared, and measured data were fit to a four parameter, Fung-type hyperelastic constitutive model. Artery behavior was nonlinear and anisotropic, with considerably greater resistance to deformation in the axial direction than around the circumference. Results from axial failure tests of pressurized vessels resulted in a small shift in stress-stretch response compared to previously reported data from unpressurized specimens. These results further define the biaxial response of the cerebral arteries and provide data required for more rigorous study of head injury mechanisms and development of cerebrovascular disease.
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影响因子：
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