Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly?
Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly?
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核体:粘性蛋白质的随机聚集体或大分子组件的坩埚?
DOI:
10.1016/j.devcel.2009.10.017
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发表时间:
2009-11
影响因子:
11.8
通讯作者:
Rajendra TK
中科院分区:
文献类型:
--
作者:
Matera AG;Izaguire-Sierra M;Praveen K;Rajendra TK
The principles of self-assembly and self-organization are major tenets of molecular and cellular biology. Governed by these principles, the eukaryotic nucleus is composed of numerous subdomains and compartments, collectively described as nuclear bodies. Emerging evidence reveals that associations within and between various nuclear bodies and genomic loci are dynamic and can change in response to cellular signals. This review will discuss recent progress in our understanding of how nuclear body components come together, what happens when they form, and what benefit these subcellular structures may provide to the tissues or organisms in which they are found.
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