Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly?

Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly?
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核体:粘性蛋白质的随机聚集体或大分子组件的坩埚?

DOI:
10.1016/j.devcel.2009.10.017
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发表时间:
2009-11
期刊:
影响因子:
11.8
通讯作者:
Rajendra TK
Rajendra TK
中科院分区:
生物学1区
文献类型:
--
作者:
Matera AG;Izaguire-Sierra M;Praveen K;Rajendra TK

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自组装和自组织原理是分子和细胞生物学的主要原理。在这些原则的支配下,真核生物的细胞核由许多子结构域和区室组成,统称为核体。新出现的证据表明,各种核体和基因组位点内部和之间的关联是动态的,可以响应细胞信号而改变。这篇综述将讨论我们对核体成分是如何聚集在一起的,它们形成时发生了什么,以及这些亚细胞结构可能为它们所在的组织或生物体提供什么好处的理解的最新进展。
The principles of self-assembly and self-organization are major tenets of molecular and cellular biology. Governed by these principles, the eukaryotic nucleus is composed of numerous subdomains and compartments, collectively described as nuclear bodies. Emerging evidence reveals that associations within and between various nuclear bodies and genomic loci are dynamic and can change in response to cellular signals. This review will discuss recent progress in our understanding of how nuclear body components come together, what happens when they form, and what benefit these subcellular structures may provide to the tissues or organisms in which they are found.
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