Mitotic recombination in yeast: what we know and what we don't know.
Mitotic recombination in yeast: what we know and what we don't know.
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DOI：
10.1016/j.gde.2021.07.002
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发表时间：
2021-12
影响因子：
4
通讯作者：
Petes TD
中科院分区：
文献类型：
--
作者：
Jinks-Robertson S;Petes TD
酿酒酵母是在有丝分裂过程中修复靶向双链断裂的主要重组机制/模型的定义的最前沿。这些模型中的每一个都预测了特定的分子中间体以及遗传结果。最近使用单核苷酸多态性来跟踪重组产物中的序列交换，提供了关于相应中间体的前所未有的详细程度和不同机制的利用程度。这种方法还揭示了经典模型无法预测的复杂性，这表明需要对这些模型进行修改。目前的数据与大多数同源物间自发有丝分裂重组事件由双链断裂引发一致。此外，姐妹染色单体比同源体更适合作为修复模板。
Saccharomyces cerevisiae is at the forefront of defining the major recombination mechanisms/models that repair targeted double-strand breaks during mitosis. Each of these models predicts specific molecular intermediates as well as genetic outcomes. Recent use of single-nucleotide polymorphisms to track the exchange of sequences in recombination products has provided an unprecedented level of detail about the corresponding intermediates and the extents to which different mechanisms are utilized. This approach also has revealed complexities that are not predicted by canonical models, suggesting that modifications to these models are needed. Current data are consistent with the initiation of most inter-homolog spontaneous mitotic recombination events by a double-strand break. In addition, the sister chromatid is preferred over the homolog as a repair template.
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影响因子：
11.4
作者：
Aylon, Y;Liefshitz, B;Kupiec, M
通讯作者：
Kupiec, M
DOI：
10.1534/g3.115.023317
发表时间：
2015-10-23
期刊：
G3 (Bethesda, Md.)
影响因子：
--
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影响因子：
64.8
作者：
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Steinmetz, Lars M.
影响因子：
4.5
作者：
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