A Long Fragment Aligner called ALFALFA.
A Long Fragment Aligner called ALFALFA.
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DOI:
10.1186/s12859-015-0533-0
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发表时间:
2015-05-15
影响因子:
3
通讯作者:
Dawyndt P
中科院分区:
文献类型:
--
作者:
Vyverman M;Baets BD;Fack V;Dawyndt P
Rapid evolutions in sequencing technology force read mappers into flexible adaptation to longer reads, changing error models, memory barriers and novel applications. ALFALFA achieves a high performance in accurately mapping long single-end and paired-end reads to gigabase-scale reference genomes, while remaining competitive for mapping shorter reads. Its seed-and-extend workflow is underpinned by fast retrieval of super-maximal exact matches from an enhanced sparse suffix array, with flexible parameter tuning to balance performance, memory footprint and accuracy. ALFALFA is open source and available at http://alfalfa.ugent.be. The online version of this article (doi:10.1186/s12859-015-0533-0) contains supplementary material, which is available to authorized users.
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