Multiple regulation of STE2, a mating-type-specific gene of Saccharomyces cerevisiae

Multiple regulation of STE2, a mating-type-specific gene of Saccharomyces cerevisiae
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酿酒酵母交配型特异性基因 STE2 的多重调控

DOI:
10.1128/mcb.6.6.2106-2114.1986
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发表时间:
1986
影响因子:
5.3
通讯作者:
V. Mackay
V. Mackay
中科院分区:
生物学2区
文献类型:
--
作者:
A. Hartig;J. Holly;G. Saari;V. Mackay

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酿酒酵母STE 2基因,这是所需的信息素的反应和接合,特别是在交配型细胞,被克隆的ste 2突变的互补。MAT α 2基因产物抑制了STE 2的转录,因此仅在α或mat α 2菌株中检测到1.4-脱氢酶STE 2 RNA,而在α或α/α细胞中检测不到。然而,STE 2 RNA水平也增加了交配信息素α因子,并在非特异性STE 4基因突变的菌株中降低。因此,细胞中STE 2表达的调节通过几种机制实现。
The Saccharomyces cerevisiae STE2 gene, which is required for pheromone response and conjugation specifically in mating-type a cells, was cloned by complementation of the ste2 mutation. Transcription of STE2 is repressed by the MAT alpha 2 gene product, so that the 1.4-kilobase STE2 RNA is detected only in a or mat alpha 2 strains, not in alpha or a/alpha cells. However, STE2 RNA levels are also increased by the mating pheromone alpha-factor and decreased in strains bearing mutations in the nonspecific STE4 gene. Regulation of STE2 expression in a cells is therefore achieved by several mechanisms.
DOI: 10.1073/pnas.81.4.1144
发表时间: 1984
影响因子: 11.1
作者:
Stetler,GL;Thorner,J
通讯作者: Thorner,J
DOI: 10.1016/s0021-9258(18)33174-0
发表时间: 1983-01
期刊: The Journal of biological chemistry
影响因子: --
作者:
C. Denis;J. Ferguson;E. Young
通讯作者: C. Denis;J. Ferguson;E. Young
DOI: 10.1073/pnas.80.10.3035
发表时间: 1983-01-01
期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子: --
作者:
JENSEN, R;SPRAGUE, GF;HERSKOWITZ, I
通讯作者: HERSKOWITZ, I
DOI: 10.1016/0022-2836(84)90315-2
发表时间: 1984-01-01
影响因子: 5.6
作者:
STERN, M;JENSEN, R;HERSKOWITZ, I
通讯作者: HERSKOWITZ, I