Association between linear measurements of corpus callosum and gait in the elderly.
Association between linear measurements of corpus callosum and gait in the elderly.
复制标题
老年人的call体和步态的线性测量之间的关联。
DOI：
10.1007/s00330-013-2818-x
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发表时间：
2013-08
影响因子：
5.9
通讯作者：
Bhadelia RA
中科院分区：
文献类型：
--
作者：
Brodoefel H;Ramachandran R;Pantol G;Bergethon P;Qiu WQ;Scott T;Rojas R;Horger M;Rosenberg I;Bhadelia RA
胼胝体（CC）的分割和扩散张量成像与步态障碍有关。然而，这样的测量在临床常规中是不切实际的。本研究的目的是评估CC厚度的简单线性测量与步态之间的关联。272名社区居民受试者接受了神经系统评估和脑MRI检查。正中矢状位重建T1加权图像用于确定CC厚度。通过多变量回归评估步态测量与临床评价的相关性，控制大量临床和影像学混杂因素。此外，比较了无、中度或重度步态障碍亚组之间CC厚度的差异。在单因素分析中，CC的厚度和体部而不是压部的厚度与姿势稳定性相关（P<0.01）。多元回归分析显示，CC层厚度是唯一与步态独立相关的影像学变量（P=0.01）。高和低（P=0.0003）或高和中等（P=0.001）跌倒风险的受试者之间的膝厚度有显着差异。CC肌萎缩是老年人步态障碍的影像学标志，提示跌倒风险较高。CC的简单线性测量可以帮助步态障碍患者的MRI评估。
Segmentation and diffusion-tensor-imaging of the corpus callosum (CC) have been linked to gait impairment. However, such measurements are impracticable in clinical routine. The purpose of this study was to evaluate the association between simple linear measurements of CC thickness with gait. Two hundred and seventy-two community-dwelling subjects underwent neurological assessment and brain MRI. Mid-sagittal reformats of T1-weighted images were used to determine CC thickness. The association of measurements with clinical evaluation of gait was assessed by multivariate regression, controlling for numerous clinical and imaging confounders. Differences in CC thickness were, moreover, compared between subgroups with no, moderate or severe impairment of gait. In univariate analyses, thickness of the genu and body of CC but not the splenium were associated with postural stability (P<0.01). Multivariate regression revealed thickness of CC genu as the only imaging variable independently associated with gait (P=0.01). Genu thickness was significantly different between subjects with high and low (P=0.0003) or high and moderate (P=0.001) risk of fall. Atrophy of the CC genu is an imaging marker of gait impairment in the elderly suggesting higher risk of fall. Simple linear measurements of CC can help in MRI evaluation of patients with gait impairment.
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影响因子：
2
作者：
Bloem, BR;Valkenburg, VV;van Dijk, JG
通讯作者：
van Dijk, JG
影响因子：
6.6
作者：
WU, JC;BUCHSBAUM, MS;LOTTENBERG, S
通讯作者：
LOTTENBERG, S
DOI：
10.1111/j.1532-5415.1986.tb05480.x
发表时间：
1986-02-01
影响因子：
6.3
作者：
TINETTI, ME
通讯作者：
TINETTI, ME
影响因子：
2.9
作者：
PANDYA, DN;KAROL, EA;HEILBRON.D
通讯作者：
HEILBRON.D
DOI：
10.1097/phm.0b013e31823caeea
发表时间：
2012-01-01
影响因子：
3
作者：
Suttanon, Plaiwan;Hill, Keith D.;Dodd, Karen J.
通讯作者：
Dodd, Karen J.