Antiangiogenic tocotrienol derivatives from Garcinia amplexicaulis.
Antiangiogenic tocotrienol derivatives from Garcinia amplexicaulis.
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来自藤黄果的抗血管生成生育三烯酚衍生物。
DOI：
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发表时间：
2013
影响因子：
5.1
通讯作者：
D. Guilet
中科院分区：
文献类型：
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作者：
A. Lavaud;P. Richomme;M. Litaudon;R. Andriantsitohaina;D. Guilet
植物化学研究的二氯甲烷提取物从藤茎树皮导致四个新的生育三烯酚（1-4）的分离，两个已知的生育三烯酚，两个三萜，和吨酮也被分离。其结构主要通过NMR和MS方法确定。分离的主要化合物，δ-amplexichromanol（1）和γ-amplexichromanol（2），使用Matrigel测定评价VEGF诱导的血管生成。化合物1和2在低纳摩尔范围内抑制VEGF诱导的人原代内皮细胞的体外血管生成。它们抑制VEGF诱导的内皮细胞增殖的能力部分解释了这种活性，尽管δ-amplexichromanol（1）也阻止了粘附和迁移过程。
Phytochemical investigation of a dichloromethane extract from Garcinia amplexicaulis stem bark led to the isolation of four new tocotrienols (1-4); two known tocotrienols, two triterpenes, and a xanthone were also isolated. Their structures were mainly established using NMR and MS methods. The main compounds isolated, δ-amplexichromanol (1) and γ-amplexichromanol (2), were evaluated on VEGF-induced angiogenesis using a Matrigel assay. Compounds 1 and 2 inhibited in vitro angiogenesis of VEGF-induced human primary endothelial cells in the low nanomolar range. Their capacity to inhibit VEGF-induced proliferation of endothelial cells partially explained this activity, although δ-amplexichromanol (1) also prevented adhesion and migration processes.
影响因子：
4.3
作者：
Velazquez, Omaida C.
通讯作者：
Velazquez, Omaida C.