Analysis of Clonality in Cutaneous T Cell Lymphoma and Associated Diseases
Analysis of Clonality in Cutaneous T Cell Lymphoma and Associated Diseases
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皮肤 T 细胞淋巴瘤及相关疾病的克隆性分析
DOI：
10.1111/j.1749-6632.2001.tb03707.x
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发表时间：
2001
影响因子：
5.2
通讯作者：
GARY S. Woody
中科院分区：
文献类型：
--
作者：
GARY S. Woody
Abstract: The T cell receptor (TCR) is the antigen‐specific receptor for T cells. During its differentiation, each T cell undergoes rearrangement of its TCR genes. This results in novel nucleotide sequences that constitute a unique signature or fingerprint for each T cell and all its clonal progeny. Analysis of TCR gene rearrangements in cutaneous T cell lymphoma (CTCL) has lead to several findings concerning CTCL tumor biology. First, like most other lymphomas, CTCL is a monoclonal lymphoproliferative disorder. Second, rather than being truly a cutaneous lymphoma, CTCL is actually a lymphoma of the skin‐associated lymphoid tissue (SALT). Even when disease appears confined to the skin clinically, there can be low‐level trafficking of tumor cells through the peripheral lymph nodes via the lymphatics and blood vessels. Furthermore, CTCL is a mature SALT lymphoma capable of trafficking to sites of cutaneous inflammation analogous to normal SALT T cells. Third, the earliest manifestation of CTCL may be “clonal dermatitis.” This is a form of chronic dermatitis that harbors a dominant T cell clone but lacks histologic features diagnostic for CTCL. About 25% of clonal dermatitis cases progress to overt CTCL within five years. Fourth, other lymphoproliferative disorders that are associated with CTCL share the same TCR gene rearrangements and therefore arise as subclones of the original tumor. These include lymphomatoid papulosis, large‐cell lymphoma, and Hodgkin's disease.
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蕈样肉芽肿和皮肤病性淋巴结病中 T 细胞受体基因的克隆重排。
DOI：
10.1056/nejm198508293130903
发表时间：
1985
期刊：
The New England journal of medicine
影响因子：
--
作者：
Weiss,LM;Hu,E;Wood,GS;Moulds,C;Cleary,ML;Warnke,R;Sklar,J
通讯作者：
Sklar,J
皮肤 T 细胞淋巴瘤中克隆 T 细胞定位于表皮。
影响因子：
13.8
作者：
Fivenson,DP;Hanson,CA;Nickoloff,BJ
通讯作者：
Nickoloff,BJ
通过聚合酶链反应和变性梯度凝胶电泳 (PCR/DGGE) 检测早期蕈样肉芽肿/Sezary 综合征中克隆 T 细胞受体 γ 基因重排。
DOI：
10.1111/1523-1747.ep12389114
发表时间：
1994
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Wood,GS;Tung,RM;Haeffner,AC;Crooks,CF;Liao,S;Orozco,R;Veelken,H;Kadin,ME;Koh,H;Heald,P
通讯作者：
Heald,P
蕈样肉芽肿患者氮芥致过敏性接触性皮炎低水平肿瘤细胞的检测
DOI：
10.1111/1523-1747.ep12345517
发表时间：
1996
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Veelken,H;Sklar,JL;Wood,GS
通讯作者：
Wood,GS
蕈样肉芽肿的转化：T细胞受体β基因分析表明斑块型蕈样肉芽肿和CD30大细胞淋巴瘤有共同的克隆起源。
DOI：
10.1111/1523-1747.ep12365416
发表时间：
1993
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Wood,GS;Bahler,DW;Hoppe,RT;Warnke,RA;Sklar,JL;Levy,R
通讯作者：
Levy,R