Effects of the number of removed lymph nodes on survival outcome in patients with sentinel node-negative breast cancer.
Effects of the number of removed lymph nodes on survival outcome in patients with sentinel node-negative breast cancer.
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前哨淋巴结阴性乳腺癌患者淋巴结切除数量对生存结局的影响。
DOI：
10.1186/s12957-021-02418-9
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发表时间：
2021-10-19
影响因子：
3.2
通讯作者：
Valerio MR
中科院分区：
文献类型：
--
作者：
Cipolla C;Galvano A;Vieni S;Saputo F;Lupo S;Latteri M;Graceffa G;Valerio MR
前哨淋巴结活检是临床淋巴结阴性患者腋窝分期的金标准手术技术。然而，它仍然是不确定的最佳前哨淋巴结（SLN）的数量被删除，以减少假阴性率。本研究的目的是调查是否有一个单一的阴性SLN患者的预后比那些有两个或两个以上的阴性SLN。对大量SLN阴性乳腺癌患者进行了回顾性分析。根据切除的SLN数量评估生存结局和局部复发率。其次，探讨了不同辅助治疗对无病生存期的贡献。统计学分析包括卡方、Wilcoxon-Mann-Whitney检验和Kaplan-Meier生存分析。共有1080例患者入选本研究。第一组包括328例患者，其中一个单一的SLN被检索，第二组包括752例患者，其中两个或两个以上的SLN被检索。SLN = 1组与SLN > 1组的中位DFS（64.9 vs 41.4）无相关差异（HR 0.76，CI 95% 0.39-1.46; p = 0.38）。如果与SLN > 1相比，仅在SLN = 1的HT治疗患者中显示mDFS的统计学显著差异（100.6个月vs 35.3个月）。切除的SNL数量与mDFS之间可能存在关系。然而，我们的研究结果显示，除了接受激素治疗的一部分患者外，SLN = 1组与SLN > 1组的中位DFS没有相关差异。
Sentinel lymph node biopsy is the gold standard surgical technique for axillary staging in patients with clinically node-negative. However, it is still uncertain what is the optimal number of sentinel lymph nodes (SLNs) to be removed to reduce the false-negative rate. The aim of this study was to investigate whether patients with a single negative SLN have a worse prognosis than those with two or more negative SLNs. A retrospective review was conducted on a large series of SLN-negative breast cancer patients. Survival outcomes and regional recurrence rate were evaluated according to the number of removed SLNs. Secondly, the contribution of different adjuvant therapies on disease-free survival was explored. Statistical analysis included the chi-square, Wilcoxon–Mann–Whitney test, and Kaplan–Meier survival analysis. A total of 1080 patients were included in the study. A first group consisted of 328 patients in whom a single SLN was retrieved, and a second group consisted of 752 patients in whom two or more SLNs were retrieved. There was no relevant difference in median DFS (64.9 vs 41.4) for SLN = 1 vs SLN > 1 groups (HR 0.76, CI 95% 0.39–1.46; p = 0.38). A statistically significant difference in mDFS was showed only for HT-treated patients who were SLN = 1 if compared to SLN > 1 (100.6 months versus 35.3 months). There is likely a relationship between the number of resected SNL and mDFS. Our results, however, showed no relevant difference in median DFS for SLN = 1 vs SLN > 1 group, except for a subset of the patients treated with hormone therapy.
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有多少个哨兵淋巴结足以在T1-2乳腺癌中进行准确的腋窝分期？
影响因子：
2.4
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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影响因子：
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作者：
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影响因子：
3.2
作者：
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通讯作者：
Shen, Kunwei