Gastrointestinal disorders associated with migraine: A comprehensive review.
Gastrointestinal disorders associated with migraine: A comprehensive review.
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DOI：
10.3748/wjg.v22.i36.8149
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发表时间：
2016-09-28
影响因子：
4.3
通讯作者：
Marfil-Rivera A
中科院分区：
文献类型：
--
作者：
Cámara-Lemarroy CR;Rodriguez-Gutierrez R;Monreal-Robles R;Marfil-Rivera A
偏头痛是一种反复发作且通常致残的原发头痛疾病，影响超过17%的女性和5%-8%的男性。偏头痛的易感性是多因素的，遗传、激素和环境因素都起着重要作用。偏头痛的生理病理机制很复杂，目前仍不完全清楚。许多不同的神经肽、神经递质和大脑通路都与此有关。与偏头痛相关的多种机制和途径，已发现多种多系统共病(如心血管、精神和其他神经系统疾病)与偏头痛密切相关。最近的报道表明，与普通人群相比，偏头痛患者胃肠道(GI)紊乱的频率增加。幽门螺杆菌感染、肠易激综合征、胃瘫、肝胆疾病、乳糜泻和微生物区系的改变与偏头痛的发生有关。涉及肠脑轴的几种机制，如炎症和血管活性介质传递到循环系统的慢性炎症反应，肠道微生物区系对肠道免疫环境的调节，以及自主神经和肠道神经系统的功能障碍，已被假设解释这些联系。然而，偏头痛与肠脑轴相关的确切机制和通路还需要充分阐明。在这篇综述中，我们综述了将偏头痛与胃肠道疾病联系起来的现有文献。我们讨论了可能的生理病理机制、临床意义以及未来几个感兴趣的研究领域。
Migraine is a recurrent and commonly disabling primary headache disorder that affects over 17% of women and 5%-8% of men. Migraine susceptibility is multifactorial with genetic, hormonal and environmental factors all playing an important role. The physiopathology of migraine is complex and still not fully understood. Many different neuropeptides, neurotransmitters and brain pathways have been implicated. In connection with the myriad mechanisms and pathways implicated in migraine, a variety of multisystemic comorbidities (e.g., cardiovascular, psychiatric and other neurological conditions) have been found to be closely associated with migraine. Recent reports demonstrate an increased frequency of gastrointestinal (GI) disorders in patients with migraine compared with the general population. Helicobacter pylori infection, irritable bowel syndrome, gastroparesis, hepatobiliary disorders, celiac disease and alterations in the microbiota have been linked to the occurrence of migraine. Several mechanisms involving the gut-brain axis, such as a chronic inflammatory response with inflammatory and vasoactive mediators passing to the circulatory system, intestinal microbiota modulation of the enteric immunological milieu and dysfunction of the autonomic and enteric nervous system, have been postulated to explain these associations. However, the precise mechanisms and pathways related to the gut-brain axis in migraine need to be fully elucidated. In this review, we survey the available literature linking migraine with GI disorders. We discuss the possible physiopathological mechanisms, and clinical implications as well as several future areas of interest for research.
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影响因子：
9.9
作者：
Cernuda-Morollon, Eva;Larrosa, Davinia;Pascual, Julio
通讯作者：
Pascual, Julio
DOI：
10.1016/0021-9681(82)90143-6
发表时间：
1982-01-01
期刊：
JOURNAL OF CHRONIC DISEASES
影响因子：
--
作者：
ABRAMSON, JH;GOFIN, J;EPSTEIN, LM
通讯作者：
EPSTEIN, LM
影响因子：
5
作者：
Aydinlar, Elif Ilgaz;Dikmen, Pinar Yalinay;Tozun, Nurdan
通讯作者：
Tozun, Nurdan
影响因子：
5
作者：
Aurora, SK;Kori, SH;Haseley, D
通讯作者：
Haseley, D
影响因子：
4.9
作者：
Alehan, F.;Ozcay, F.;Cemil, T.
通讯作者：
Cemil, T.