Human left ventral premotor cortex mediates matching of hand posture to object use.
Human left ventral premotor cortex mediates matching of hand posture to object use.
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DOI：
10.1371/journal.pone.0070480
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Vandemaele P
中科院分区：
文献类型：
--
作者：
Vingerhoets G;Nys J;Honoré P;Vandekerckhove E;Vandemaele P
抓取的视觉运动转换与猴子大脑中的额顶网络有关。顶猴区的人类同源基因(AIP)已被确认为顶内沟的前部(AIPS)，而与猴额叶(F5)对应的人类同源区位于运动前皮质(VPMC)的腹侧部分。动物研究的结果表明，猴子F5参与了与任务限制相关的适当手势的选择。在人类中，AIPS和vPMC的功能似乎更加复杂，每个区域对把握选择的相对贡献仍不确定。本研究旨在识别对工具物体-手势匹配难度水平敏感的大脑区域的调制。17名健康的右撇子受试者在观察熟悉的工具物体的图片和手部姿势的图片时进行了功能磁共振成像。任务是确定手势是否与之前展示的物体的功能使用相匹配。条件被操控以达到难度水平。与图片匹配控制任务相比，工具物-手姿势匹配条件在顶上、下小叶(包括AIPS)、枕中回和颞下回的几个左半球区域的调制增加。硬条件和易条件的比较选择性地调制左额下回，活动高峰位于其顶端(Brodmann区(BA)44)。我们认为，在人脑中，vPMC/BA44参与了手势与视觉和功能需求的匹配。
Visuomotor transformations for grasping have been associated with a fronto-parietal network in the monkey brain. The human homologue of the parietal monkey region (AIP) has been identified as the anterior part of the intraparietal sulcus (aIPS), whereas the putative human equivalent of the monkey frontal region (F5) is located in the ventral part of the premotor cortex (vPMC). Results from animal studies suggest that monkey F5 is involved in the selection of appropriate hand postures relative to the constraints of the task. In humans, the functional roles of aIPS and vPMC appear to be more complex and the relative contribution of each region to grasp selection remains uncertain. The present study aimed to identify modulation in brain areas sensitive to the difficulty level of tool object - hand posture matching. Seventeen healthy right handed participants underwent fMRI while observing pictures of familiar tool objects followed by pictures of hand postures. The task was to decide whether the hand posture matched the functional use of the previously shown object. Conditions were manipulated for level of difficulty. Compared to a picture matching control task, the tool object – hand posture matching conditions conjointly showed increased modulation in several left hemispheric regions of the superior and inferior parietal lobules (including aIPS), the middle occipital gyrus, and the inferior temporal gyrus. Comparison of hard versus easy conditions selectively modulated the left inferior frontal gyrus with peak activity located in its opercular part (Brodmann area (BA) 44). We suggest that in the human brain, vPMC/BA44 is involved in the matching of hand posture configurations in accordance with visual and functional demands.
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DOI：
10.1016/j.cogbrainres.2004.10.006
发表时间：
2005-03-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
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通讯作者：
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影响因子：
3.7
作者：
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通讯作者：
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影响因子：
7.8
作者：
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通讯作者：
Arbib, MA
影响因子：
5.7
作者：
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通讯作者：
Nichols, T
影响因子：
2
作者：
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通讯作者：
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