Association of Preadmission Statin Use and Mortality in Critically Ill Patients: A Meta-Analysis of Cohort Studies.
Association of Preadmission Statin Use and Mortality in Critically Ill Patients: A Meta-Analysis of Cohort Studies.
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危重患者入院前他汀类药物使用与死亡率的关联：队列研究的荟萃分析
DOI：
10.3389/fmed.2021.656694
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发表时间：
2021
影响因子：
3.9
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Yu SS;Jin J;Yao RQ;Wang BL;Hu LY;Wu GS;Sun Y
背景资料：已经进行了大量的研究来确定入院前使用他汀类药物与危重病后结局改善之间是否存在关联，但结论非常不一致。因此，本荟萃分析旨在纳入目前相关的PSM研究，以检查入院前使用他汀类药物与危重患者死亡率的相关性。研究方法：在PubMed、Web of Science、Embase电子数据库和印刷资源中检索2020年3月6日之前发表的关于入院前他汀类药物使用与危重患者死亡率之间关系的英文文章。在RevMan 5.3中分析了纳入的文章。采用Newcastle-Ottawa量表（NOS）进行质量评价，采用随机/固定效应模型计算合并OR和95%CI。我们还根据结局指标（30天、90天、住院死亡率）进行了亚组分析。结果：根据NOS，所有6项PSM观察性研究均被评估为偏倚风险较低。对于主要结局-总死亡率，6项纳入研究的合并OR（入院前使用他汀类药物vs.未使用）为0. 86（95% CI，0. 76 - 0. 97; P = 0. 02）。对于次要结局-使用机械通气，合并OR为0.94（95%CI，0.91-0.97; P = 0.0005）。30天、90天和住院死亡率的相应合并OR分别为0.67（95% CI，0.43-1.05; P = 0.08）、0.91（95% CI，0.83-1.01; P = 0.07）和0.86（95% CI，0.83-0.89; P < 0.00001）。结论：入院前使用他汀类药物与危重患者的有益结局相关，表明短期死亡率较低，机械通气使用较少，住院生存率提高。需要进一步的高质量原创研究或更科学的方法来得出明确的结论。
Background: A large number of studies have been conducted to determine whether there is an association between preadmission statin use and improvement in outcomes following critical illness, but the conclusions are quite inconsistent. Therefore, this meta-analysis aims to include the present relevant PSM researches to examine the association of preadmission use of statins with the mortality of critically ill patients. Methods: The PubMed, Web of Science, Embase electronic databases, and printed resources were searched for English articles published before March 6, 2020 on the association between preadmission statin use and mortality in critically ill patients. The included articles were analyzed in RevMan 5.3. The Newcastle-Ottawa Scale (NOS) was used to conduct quality evaluation, and random/fixed effects modeling was used to calculate the pooled ORs and 95% CIs. We also conducted subgroup analysis by outcome indicators (30-, 90-day, hospital mortality). Results: All six PSM observational studies were assessed as having a low risk of bias according to the NOS. For primary outcome—overall mortality, the pooled OR (preadmission statins use vs. no use) across the six included studies was 0.86 (95% CI, 0.76–0.97; P = 0.02). For secondary outcome—use of mechanical ventilation, the pooled OR was 0.94 (95% CI, 0.91–0.97; P = 0.0005). The corresponding pooled ORs were 0.67 (95% CI, 0.43–1.05; P = 0.08), 0.91 (95% CI, 0.83–1.01; P = 0.07), and 0.86 (95% CI, 0.83–0.89; P < 0.00001) for 30-, 90-day, and hospital mortality, respectively. Conclusions: Preadmission statin use is associated with beneficial outcomes in critical ill patients, indicating a lower short-term mortality, less use of mechanical ventilation, and an improvement in hospital survival. Further high-quality original studies or more scientific methods are needed to draw a definitive conclusion.
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DOI：
10.1186/cc13845
发表时间：
2014-04-28
期刊：
Critical care (London, England)
影响因子：
--
作者：
Bruyere R;Vigneron C;Prin S;Pechinot A;Quenot JP;Aho S;Papazian L;Charles PE
通讯作者：
Charles PE
DOI：
10.1164/rccm.201209-1718oc
发表时间：
2013-04-01
影响因子：
24.7
作者：
Kruger, Peter;Bailey, Michael;Venkatesh, Bala
通讯作者：
Venkatesh, Bala
影响因子：
9.8
作者：
Lee, M. G.;Lee, C. -C.;Chen, Y. -M.
通讯作者：
Chen, Y. -M.
影响因子：
3.7
作者：
Ma Y;Wen X;Peng J;Lu Y;Guo Z;Lu J
通讯作者：
Lu J
影响因子：
3.7
作者：
López-Cortés LE;Gálvez-Acebal J;Del Toro MD;Velasco C;de Cueto M;Caballero FJ;Muniain MA;Pascual A;Rodríguez-Baño J
通讯作者：
Rodríguez-Baño J