Two-step aberration correction: application to transcranial histotripsy.
Two-step aberration correction: application to transcranial histotripsy.
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DOI：
10.1088/1361-6560/ac72ed
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发表时间：
2022-06-10
影响因子：
3.5
通讯作者：
Xu, Zhen
中科院分区：
文献类型：
--
作者：
Lu, Ning;Hall, Timothy L.;Sukovich, Jonathan R.;Choi, Sang Won;Snell, John;McDannold, Nathan;Xu, Zhen
关键词：
相位像差校正是必要的经颅组织切片，以补偿由完整颅骨的异质性引起的局灶畸变。本文改进了先前提出的两步像差校正（AC）方法，并开发了一种适合临床环境的AC工作流程，其中首先实现了基于计算机断层扫描（CT）的分析方法，然后利用声空化发射（ACE）的冲击波进行了基于空化的方法。一个700 kHz、360个单元的半球换能器阵列能够在所有信道上发射和接收，用于经颅产生历史诱导空化并获取ACE冲击波。对于CT-AC，研究了两种射线追踪模型：开源软件Kranion中的前向射线追踪模型（换能器到焦点）和内部的后向射线追踪模型（焦点到换能器），该模型考虑了头骨中的折射和声速变化。通过将颅骨CT数据与利用声脉冲回波法重建的颅骨面图对齐，实现共配准。对于ACE- ac，通过互相关对产生气泡崩溃的ACE信号进行对齐，以估计相应的时间延迟。将3个切除的人颅骨放置在传感器阵列的2个不同位置，测试了两步法的性能。结果表明，与金标准水听器校正相比，两步AC校正可达到90±7%的峰值焦压。与无交流的病例相比，平均焦移从0.84减少到0.30 mm，焦体积从10.6减少到2.0 mm3。与单独的CT-AC或ACE-AC相比，2步AC可获得更好的重新聚焦，并且可用于经颅组织切片脑治疗的实时实施。
Phase aberration correction is essential in transcranial histotripsy to compensate for focal distortion caused by the heterogeneity of the intact skull bone. This paper improves the 2-step aberration correction (AC) method that has been previously presented and develops an AC workflow that fits in the clinical environment, in which the computed tomography (CT)-based analytical approach was first implemented, followed by a cavitation-based approach using the shockwaves from the acoustic cavitation emission (ACE). A 700 kHz, 360-element hemispherical transducer array capable of transmit-and-receive on all channels was used to transcranially generate histotripsy-induced cavitation and acquire ACE shockwaves. For CT-AC, two ray-tracing models were investigated: a forward ray-tracing model (transducer-to-focus) in the open-source software Kranion, and an in-house backward ray-tracing model (focus-to-transducer) accounting for refraction and the sound speed variation in skulls. Co-registration was achieved by aligning the skull CT data to the skull surface map reconstructed using the acoustic pulse-echo method. For ACE-AC, the ACE signals from the collapses of generated bubbles were aligned by cross-correlation to estimate the corresponding time delays. The performance of the 2-step method was tested with 3 excised human calvariums placed at 2 different locations in the transducer array. Results showed that the 2-step AC achieved 90±7% peak focal pressure compared to the gold standard hydrophone correction. It also reduced the focal shift from 0.84 to 0.30 mm and the focal volume from 10.6 to 2.0 mm3 on average compared to the no AC cases. The 2-step AC yielded better refocusing compared to either CT-AC or ACE-AC alone and can be implemented in real-time for transcranial histotripsy brain therapy.
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影响因子：
2.9
作者：
Clement, GT;Hynynen, K
通讯作者：
Hynynen, K
影响因子：
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作者：
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作者：
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DOI：
10.1109/tuffc.2014.2947
发表时间：
2014-04-01
影响因子：
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作者：
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通讯作者：
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影响因子：
3.5
作者：
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