Direct cortical hemodynamic mapping of somatotopy of pig nostril sensation by functional near-infrared cortical imaging (fNCI)
Direct cortical hemodynamic mapping of somatotopy of pig nostril sensation by functional near-infrared cortical imaging (fNCI)
复制标题
通过功能性近红外皮质成像 (fNCI) 直接绘制猪鼻孔感觉体型的皮质血流动力学图
DOI：
10.1016/j.neuroimage.2013.12.062
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发表时间：
2014
期刊：
影响因子：
5.7
通讯作者：
Watanabe E
中科院分区：
文献类型：
--
作者：
Uga M;Saito T;Sano T;Yokota H;Oguro K;Rizki EE;Mizutani T;Katura T;Dan I;Watanabe E
功能近红外光谱（fNIRS）是一种利用神经活动和区域脑血流动力学之间的耦合对人脑激活状态进行无创监测的神经成像技术。照明器和检测器一起构成光电二极管，放置在头皮上，但由于头部组织的存在，光电二极管之间的距离需要超过2.5厘米才能检测到皮层信号。尽管使用近红外光谱（fNIRS）对皮质进行直接监测已经得到了应用，但直接从皮质表面观察与感觉、运动和认知神经反应相关的血流动力学变化的高分辨率可视化尚未实现。为了获得关于皮质血流动力学的可靠信息，在经颅测量中没有信号并发症，我们设计了一种功能性近红外皮质成像（fNCI）技术。在这里，我们展示了使用fNCI技术对皮层血流动力学的时间和空间模式的第一个直接功能测量。对于fNCI，将光电二极管之间的距离设置为5mm，并使用由遮光橡胶片制成的特殊光电二极管支架来防止照明器漏光。fNCI成功检测到猪鼻孔感觉的躯体解剖，并与同一刺激部位的并发和顺序体感诱发电位（SEP）测量结果进行了比较。因此，fNCI系统实现了直接的皮层血流动力学测量，其空间分辨率与猪脑吻侧区域的SEP制图相当。本研究为实现人脑神经外科手术过程中皮层血流动力学监测迈出了重要的第一步。
Functional near-infrared spectroscopy (fNIRS) is a neuroimaging technique for the noninvasive monitoring of human brain activation states utilizing the coupling between neural activity and regional cerebral hemodynamics. Illuminators and detectors, together constituting optodes, are placed on the scalp, but due to the presence of head tissues, an inter-optode distance of more than 2.5 cm is necessary to detect cortical signals. Although direct cortical monitoring with fNIRS has been pursued, a high-resolution visualization of hemodynamic changes associated with sensory, motor and cognitive neural responses directly from the cortical surface has yet to be realized. To acquire robust information on the hemodynamics of the cortex, devoid of signal complications in transcranial measurement, we devised a functional near-infrared cortical imaging (fNCI) technique. Here we demonstrate the first direct functional measurement of temporal and spatial patterns of cortical hemodynamics using the fNCI technique. For fNCI, inter-optode distance was set at 5 mm, and light leakage from illuminators was prevented by a special optode holder made of a light-shielding rubber sheet. fNCI successfully detected the somatotopy of pig nostril sensation, as assessed in comparison with concurrent and sequential somatosensory-evoked potential (SEP) measurements on the same stimulation sites. Accordingly, the fNCI system realized a direct cortical hemodynamic measurement with a spatial resolution comparable to that of SEP mapping on the rostral region of the pig brain. This study provides an important initial step toward realizing functional cortical hemodynamic monitoring during neurosurgery of human brains.
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DOI：
10.1109/iccme.2012.6275739
发表时间：
2012
期刊：
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影响因子：
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作者：
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DOI：
--
发表时间：
1991
期刊：
The Journal of comparative neurology
影响因子：
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作者：
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