Beyond pharmaceuticals: Fit-for-purpose new approach methodologies for environmental cardiotoxicity testing.
Beyond pharmaceuticals: Fit-for-purpose new approach methodologies for environmental cardiotoxicity testing.
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DOI：
10.14573/altex.2109131
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发表时间：
2023
影响因子：
5.6
通讯作者：
Coulombe, Kareen L. K.
中科院分区：
文献类型：
--
作者：
Daley, Mark C.;Mende, Ulrike;Choi, Bum-Rak;McMullen, Patrick D.;Coulombe, Kareen L. K.
环境因素在决定心血管健康方面发挥着重要作用，但环境毒物所带来的风险的数据还不充分。体外新方法学（NAM）提供了一种很有前途的方法，可以解决传统的体内和体外试验评估心脏毒性的局限性。在药物毒性测试需求的推动下，开发用于心脏毒性分析的NAM已经取得了相当大的进展。随着对环境化学品NAM的科学和监管兴趣不断增长，需要彻底了解环境心脏毒物及其相关心脏毒性的独特特征。在这里，我们审查的关键特征，以及重要的监管和生物学考虑适合的目的NAM的环境心脏毒性。通过强调NAMs对环境心脏毒性的挑战和机遇，我们希望加速其开发，接受和应用。
Environmental factors play a substantial role in determining cardiovascular health, but data informing the risks presented by environmental toxicants is insufficient. In vitro new approach methodologies (NAMs) offer a promising approach with which to address the limitations of traditional in vivo and in vitro assays for assessing cardiotoxicity. Driven largely by the needs of pharmaceutical toxicity testing, considerable progress in developing NAMs for cardiotoxicity analysis has already been made. As the scientific and regulatory interest in NAMs for environmental chemicals continues to grow, a thorough understanding of the unique features of environmental cardiotoxicants and their associated cardiotoxicities is needed. Here, we review the key characteristics of as well as important regulatory and biological considerations for fit-for-purpose NAMs for environmental cardiotoxicity. By emphasizing the challenges and opportunities presented by NAMs for environmental cardiotoxicity we hope to accelerate their development, acceptance, and application.
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