A public genome-scale lentiviral expression library of human ORFs.

A public genome-scale lentiviral expression library of human ORFs.
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DOI:
10.1038/nmeth.1638
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发表时间:
2011-06-26
期刊:
影响因子:
48
通讯作者:
Root, David E.
Root, David E.
中科院分区:
生物学1区
文献类型:
--
作者:
Yang, Xiaoping;Boehm, Jesse S.;Yang, Xinping;Salehi-Ashtiani, Kourosh;Hao, Tong;Shen, Yun;Lubonja, Rakela;Thomas, Sapana R.;Alkan, Ozan;Bhimdi, Tashfeen;Green, Thomas M.;Johannessen, Cory M.;Silver, Serena J.;Cindy Nguyen;Murray, Ryan R.;Hieronymus, Haley;Balcha, Dawit;Fan, Changyu;Lin, Chenwei;Ghamsari, Lila;Vidal, Marc;Hahn, William C.;Hill, David E.;Root, David E.

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人类基因组的功能表征需要在功能丧失和功能获得实验中系统地调节基因表达的工具。我们描述了在多功能 Gateway 载体系统中编码的超过 16,100 个人类开放阅读框 (ORF) 的序列确认克隆集合的产生。利用这种 ORFeome 资源,我们在慢病毒载体中创建了基因组规模的表达集合,从而能够在不同的细胞类型中进行靶向实验和高通量筛选。
Functional characterization of the human genome requires tools for systematically modulating gene expression in both loss- and gain-of-function experiments. We describe the production of a sequence-confirmed, clonal collection of over 16,100 human open-reading frames (ORFs) encoded in a versatile Gateway vector system. Utilizing this ORFeome resource, we created a genome-scale expression collection in a lentiviral vector, thereby enabling both targeted experiments and high-throughput screens in diverse cell types.
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发表时间: 2005-10-20
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