Ghrelin modulates hypothalamic fatty acid-sensing and control of food intake in rainbow trout.
Ghrelin modulates hypothalamic fatty acid-sensing and control of food intake in rainbow trout.
复制标题
生长素释放肽调节虹鳟鱼的下丘脑脂肪酸感应和食物摄入控制。
DOI：
10.1530/joe-15-0391
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
J. Soengas
中科院分区：
文献类型：
--
作者：
C. Velasco;M. Librán;C. Otero;M. A. López;J. Míguez;J. M. Cerdá;J. Soengas
目前还没有关于饥饿素对下丘脑脂肪酸代谢和脂肪酸感应系统反应的可能影响的鱼类信息，而脂肪酸感应系统参与食物摄入的控制。因此，我们评估虹鳟鱼的食物摄入量，下丘脑脂肪酸传感机制和神经肽的表达参与控制食物摄入量的中枢治疗的生长激素释放肽的存在或不存在的长链脂肪酸，如油酸的反应。我们观察到虹鳟鱼胃饥饿素的促食欲作用与下丘脑脂肪酸代谢的变化和脂肪酸传感机制的抑制有关，这最终导致促食欲肽和促食欲肽的表达变化，从而增加促食欲潜力和食物摄入。此外，下丘脑脂肪酸传感系统（激活），神经肽（增强的促氧化潜力）和食物摄入量（减少）的油酸水平增加的反应被抵消的同时与生长激素释放肽治疗。这些变化提供了证据，第一次在鱼的一个可能的调节作用ghrelin的代谢调节脂肪酸的食物摄入发生在下丘脑。
There is no information available on fish as far as the possible effects of ghrelin on hypothalamic fatty acid metabolism and the response of fatty acid-sensing systems, which are involved in the control of food intake. Therefore, we assessed in rainbow trout the response of food intake, hypothalamic fatty acid-sensing mechanisms and expression of neuropeptides involved in the control of food intake to the central treatment of ghrelin in the presence or absence of a long-chain fatty acid such as oleate. We observed that the orexigenic actions of ghrelin in rainbow trout are associated with changes in fatty acid metabolism in the hypothalamus and an inhibition of fatty acid-sensing mechanisms, which ultimately lead to changes in the expression of anorexigenic and orexigenic peptides resulting in increased orexigenic potential and food intake. Moreover, the response to increased levels of oleate of hypothalamic fatty acid-sensing systems (activation), expression of neuropeptides (enhanced anorexigenic potential) and food intake (decrease) were counteracted by the simultaneous treatment with ghrelin. These changes provide evidence for the first time in fish of a possible modulatory role of ghrelin on the metabolic regulation by fatty acid of food intake occurring in the hypothalamus.
影响因子：
4.8
作者：
S. Unniappan;Xin-wei Lin;L. Cervini;J. Rivier;H. Kaiya;K. Kangawa;R. Peter
通讯作者：
S. Unniappan;Xin-wei Lin;L. Cervini;J. Rivier;H. Kaiya;K. Kangawa;R. Peter
影响因子：
29
作者：
Lopez, Miguel;Lage, Ricardo;Vidal-Puig, Antonio
通讯作者：
Vidal-Puig, Antonio