Strategies for investigating the maternal-fetal interface in the first trimester of pregnancy: What can we learn about pathology?
Strategies for investigating the maternal-fetal interface in the first trimester of pregnancy: What can we learn about pathology?
复制标题
DOI：
10.1016/j.placenta.2017.05.003
复制
发表时间：
2017-12
期刊：
影响因子：
3.8
通讯作者：
Whitley GS
中科院分区：
文献类型：
--
作者：
Cartwright JE;Whitley GS
妊娠并发症先兆子痫(PE)和胎儿生长受限(FGR)的病理机制是在人类怀孕的前三个月建立的。在正常妊娠中，蜕膜螺旋动脉转变为直径较大的非血管活性血管，能够满足发育中的胎儿对营养和氧气的日益增长的需求。这种转变的中断与PE和FGR有关。人们对这些早期妊娠变化是如何正常调节的知之甚少，更不知道它们在复杂的怀孕中是如何受到影响的。母体细胞和胎盘细胞之间的相互作用对于妊娠的进展是必不可少的，这篇综述将总结这一领域研究中的挑战。我们将讨论在这个最动态和最关键的时刻，对发生PE/FGR风险增加的妊娠的早期研究如何开始提供关于怀孕的有价值的信息。我们将讨论在哪里有进一步发展这些研究的空间，通过提高在早期阶段识别不良妊娠的能力，通过整合来自同一妊娠的多种细胞类型的信息，以及通过改进我们在体外模拟母婴界面的方法。PE/FGR的病理表现始于妊娠早期。对PE/FGR风险增加的孕妇进行调查提供了有价值的信息。随着在识别不良妊娠方面的进展，这一点将进一步改善。
The pathologies of the pregnancy complications pre-eclampsia (PE) and fetal growth restriction (FGR) are established in the first trimester of human pregnancy. In a normal pregnancy, decidual spiral arteries are transformed into wide diameter, non-vasoactive vessels capable of meeting the increased demands of the developing fetus for nutrients and oxygen. Disruption of this transformation is associated with PE and FGR. Very little is known of how these first trimester changes are regulated normally and even less is known about how they are compromised in complicated pregnancies. Interactions between maternal and placental cells are essential for pregnancy to progress and this review will summarise the challenges in investigating this area. We will discuss how first trimester studies of pregnancies with an increased risk of developing PE/FGR have started to provide valuable information about pregnancy at this most dynamic and crucial time. We will discuss where there is scope to progress these studies further by refining the ability to identify compromised pregnancies at an early stage, by integrating information from many cell types from the same pregnancy, and by improving our methods for modelling the maternal-fetal interface in vitro. Pathology of PE/FGR begins in the first trimester. Investigating pregnancies with increased risk of PE/FGR is giving valuable information. This will improve further with advances in identifying compromised pregnancies.
登录
查看更多内容
在子宫耐药性高的早期人类妊娠中，血管重塑的决定性自然杀伤细胞调节受损。
影响因子：
7.3
作者：
Fraser, Rupsha;Whitley, Guy Stj;Johnstone, Alan P.;Host, Amanda J.;Sebire, Neil J.;Thilaganathan, Baskaran;Cartwright, Judith E.
通讯作者：
Cartwright, Judith E.
影响因子：
3.8
作者：
Chen, Q;Stone, PR;Chamley, LW
通讯作者：
Chamley, LW
影响因子：
6
作者：
Harris, Lynda K.;Keogh, Rosemary J.;Whitley, Guy St J.
通讯作者：
Whitley, Guy St J.
DOI：
10.1016/j.bpobgyn.2010.10.009
发表时间：
2011-06-01
影响因子：
5.5
作者：
Pijnenborg, R.;Vercruysse, L.;Brosens, I.
通讯作者：
Brosens, I.
影响因子：
6.1
作者：
Kam, EPY;Gardner, L;King, A
通讯作者：
King, A