Correlation between cytotoxic activities and reduction potentials of heterocyclic quinones.
Correlation between cytotoxic activities and reduction potentials of heterocyclic quinones.
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DOI：
10.3390/molecules15096559
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发表时间：
2010-09-20
期刊：
影响因子：
--
通讯作者：
Yamori T
中科院分区：
文献类型：
--
作者：
Koyama J;Morita I;Yamori T
为了在天然产物或合成产物中寻找可能的抗肿瘤药物或抗肿瘤促进剂，我们采用循环伏安法测定了杂环醌在pH 7.2的磷酸盐缓冲液中的还原-氧化电位。我们测定了12种杂环醌类抗肿瘤药物候选物对一组39种人类癌细胞系（JFCR 39）的生长抑制和细胞毒活性。对JFCR 39的50%生长抑制（GI 50）所需的杂环醌的平均浓度范围为0.045至13.2 μM，对JFCR 39的50%致死浓度（LC 50）范围为0.398至77.7 μM。杂环醌类化合物的GI_（50）和LC_（50）的平均值与其还原电位呈显著正相关。这些结果表明，还原-氧化电位可能是一个有用的方法，发现新的抗肿瘤药物。
To search for possible anti-tumor agents or anti-tumor promoters among natural or synthetic products, we used cyclic voltammetry to determine the reduction-oxidation potentials of heterocyclic quinones in phosphate buffer at pH 7.2. We determined the growth inhibitory- and cytotoxic activities of 12 heterocyclic quinone anti-tumor agent candidates against a panel of 39 human cancer cell lines (JFCR39). The average concentrations of the heterocyclic quinones required for 50% growth inhibition (GI50) against JFCR39 ranged from 0.045 to 13.2 μM, and the 50% lethal concentration (LC50) against JFCR39 ranged from 0.398 to 77.7 μM. The average values of GI50 or LC50 of the heterocyclic quinones correlated significantly with their reduction potentials. These results suggested that reduction-oxidation potentials could be a useful method for the discovery of novel antitumor agents.
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影响因子：
2.7
作者：
Koyama, Junko;Nisino, Yu;Tokuda, Harukuni
通讯作者：
Tokuda, Harukuni
DOI：
10.1093/jnci/83.11.757
发表时间：
1991-06-05
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
MONKS, A;SCUDIERO, D;BOYD, M
通讯作者：
BOYD, M
影响因子：
3
作者：
STEWART, JJP
通讯作者：
STEWART, JJP
影响因子：
15
作者：
PRATT, YT;DRAKE, NL
通讯作者：
DRAKE, NL
影响因子：
8.4
作者：
Kong, Dexin;Dan, Shingo;Yamori, Takao
通讯作者：
Yamori, Takao