Electrochemically-gated delivery of analyte bands in microfluidic devices using bipolar electrodes.

Electrochemically-gated delivery of analyte bands in microfluidic devices using bipolar electrodes.
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使用双极电极在微流体装置中电化学门控分析物条带的输送。

DOI:
10.1039/c3lc50321f
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发表时间:
2013
期刊:
影响因子:
6.1
通讯作者:
R. Crooks
R. Crooks
中科院分区:
工程技术1区
文献类型:
--
作者:
K. Scida;E. Sheridan;R. Crooks

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描述了一种使用简单的微流体结构来控制分析物的富集、分离和递送到不同的次级微通道中的方法。该方法基于双极电化学,只需要容易制造的电极和低压直流电源:不需要泵或阀。在两个驱动电极之间施加电压时,激活无源双极电极(BPE),导致形成局部电场梯度。该梯度导致一对荧光分析物在主微流体通道内的分离和富集。随后,可以激活其他被动BPE以将富集的示踪剂递送到单独的二级微通道。该方法的原理和性能支撑的描述。
A method for controlling enrichment, separation, and delivery of analytes into different secondary microchannels using simple microfluidic architecture is described. The approach, which is based on bipolar electrochemistry, requires only easily fabricated electrodes and a low-voltage DC power supply: no pumps or valves are necessary. Upon application of a voltage between two driving electrodes, passive bipolar electrodes (BPEs) are activated that result in formation of a local electric field gradient. This gradient leads to separation and enrichment of a pair of fluorescent analytes within a primary microfluidic channel. Subsequently, other passive BPEs can be activated to deliver the enriched tracers to separate secondary microchannels. The principles and performance underpinning the method are described.
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发表时间: 2002-06-01
影响因子: 7.4
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