Event-related potential and lexical decision task in dyslexic adults: Lexical and lateralization effects.
Event-related potential and lexical decision task in dyslexic adults: Lexical and lateralization effects.
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DOI：
10.3389/fpsyg.2022.852219
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发表时间：
2022
影响因子：
3.8
通讯作者：
Macedo, Elizeu Coutinho
中科院分区：
文献类型：
--
作者：
Silva, Patricia Botelho;Oliveira, Darlene Godoy;Cardoso, Amanda Douat;Laurence, Paulo Guirro;Boggio, Paulo Sergio;Macedo, Elizeu Coutinho
关键词：
发展性阅读障碍是一种特殊的学习障碍，表现为认知和神经生物学障碍，这些障碍与整个发育过程中的不同大脑激活模式有关，并持续到成年。词汇决策任务，连同脑电图（EEG）的措施，具有很大的时间精度，允许捕获的认知过程中的任务，并可以帮助理解改变成人诵读困难症的大脑激活过程。高密度EEG允许通过事件相关电位（ERP）进行时间分析。本研究的目的是比较和测量发展性阅读障碍和良好阅读者的ERP模式，并描述和比较各组之间的阅读模式。20名被诊断为发展性阅读障碍的大学成年人和23名健康的阅读障碍成年人参加了这项研究。研究人员通过智力、语音意识、阅读和写作以及词汇判断测试（LDT）对这些小组进行了评估。在LDT期间，使用128通道EEG设备记录ERP。分析P100枕区、N170枕颞区、N400顶心区和LPC顶心区的ERP。结果显示，在阅读、语音意识和写作测试中，两组学生的认知能力存在差异，但在智力测试中没有差异。此外，就半球偏侧性而言，两组的ERP的脑激活模式不同，阅读障碍组的N170在右半球的振幅较高，而对照组的模式相反，并且与LDT的项目相关的特异性，因为阅读障碍组的N400对单词更负，而在对照组中，这种ERP在假词中更为明显。这些结果对于理解发展性阅读障碍的不同大脑模式非常重要，并且可以根据轮廓中发现的变化更好地指导未来的干预措施。
Developmental dyslexia is a specific learning disorder that presents cognitive and neurobiological impairments related to different patterns of brain activation throughout development, continuing in adulthood. Lexical decision tasks, together with electroencephalography (EEG) measures that have great temporal precision, allow the capture of cognitive processes during the task, and can assist in the understanding of altered brain activation processes in adult dyslexics. High-density EEG allows the use of temporal analyses through event-related potentials (ERPs). The aim of this study was to compare and measure the pattern of ERPs in adults with developmental dyslexia and good readers, and to characterize and compare reading patterns between groups. Twenty university adults diagnosed with developmental dyslexia and 23 healthy adult readers paired with dyslexics participated in the study. The groups were assessed in tests of intelligence, phonological awareness, reading, and writing, as well as through the lexical decision test (LDT). During LDT, ERPs were recorded using a 128-channel EEG device. The ERPs P100 occipital, N170 occipito-temporal, N400 centro-parietal, and LPC centro-parietal were analyzed. The results showed a different cognitive profile between the groups in the reading, phonological awareness, and writing tests but not in the intelligence test. In addition, the brain activation pattern of the ERPs was different between the groups in terms of hemispheric lateralization, with higher amplitude of N170 in the dyslexia group in the right hemisphere and opposite pattern in the control group and specificities in relation to the items of the LDT, as the N400 were more negative in the Dyslexia group for words, while in the control group, this ERP was more pronounced in the pseudowords. These results are important for understanding different brain patterns in developmental dyslexia and can better guide future interventions according to the changes found in the profile.
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