Donor-Recipient Non-HLA Variants, Mismatches and Renal Allograft Outcomes: Evolving Paradigms.
Donor-Recipient Non-HLA Variants, Mismatches and Renal Allograft Outcomes: Evolving Paradigms.
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DOI：
10.3389/fimmu.2022.822353
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
尽管急性同种异体移植排斥反应的发生率显著提高，但同种异体肾脏移植寿命的相应提高尚未实现，这是一个激烈的研究努力的来源。新出现的转化数据和自然历史研究表明，抗供体免疫机制在大多数同种异体移植物丢失而没有患者死亡的病例中发挥作用，即使没有发现明显的急性排斥证据。在供体和受体基因组水平上，作为器官分配过程的一部分，经常评估供体和受体对之间高度多态性HLA基因的差异，并用于患者量身定制的诱导和维持免疫抑制。然而，越来越多的数据表明，在HLA位点之外，供体和受体基因中的特定变异会诱导供体器官或受体免疫系统的表型变化，从而影响移植结果。在移植的供体-受体基因组相互作用过程中，也提出了这些非hla位点“错配”的新机制。在这里，我们回顾了最近评估非hla基因位点和全基因组供体-受体错配在肾移植结果中的作用的重要数据。
Despite significant improvement in the rates of acute allograft rejection, proportionate improvements in kidney allograft longevity have not been realized, and are a source of intense research efforts. Emerging translational data and natural history studies suggest a role for anti-donor immune mechanisms in a majority of cases of allograft loss without patient death, even when overt evidence of acute rejection is not identified. At the level of the donor and recipient genome, differences in highly polymorphic HLA genes are routinely evaluated between donor and recipient pairs as part of organ allocation process, and utilized for patient-tailored induction and maintenance immunosuppression. However, a growing body of data have characterized specific variants in donor and recipient genes, outside of HLA loci, that induce phenotypic changes in donor organs or the recipient immune system, impacting transplant outcomes. Newer mechanisms for “mismatches” in these non-HLA loci have also been proposed during donor–recipient genome interactions with transplantation. Here, we review important recent data evaluating the role of non-HLA genetic loci and genome-wide donor-recipient mismatches in kidney allograft outcomes.
影响因子：
3.7
作者：
Arthur VL;Li Z;Cao R;Oetting WS;Israni AK;Jacobson PA;Ritchie MD;Guan W;Chen J
通讯作者：
Chen J
影响因子：
--
作者：
Stapleton CP;Lord GM;UK and Ireland Renal Transplant Consortium;Conlon PJ;Cavalleri GL
通讯作者：
Cavalleri GL
影响因子：
4.9
作者：
Park H;Lee N;In JW;Roh EY;Park KU;Shin S;Yang J;Song EY
通讯作者：
Song EY