Association of Foxp3 Polymorphism With Allograft Outcome in Kidney Transplantation.
Association of Foxp3 Polymorphism With Allograft Outcome in Kidney Transplantation.
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DOI：
10.3343/alm.2017.37.5.420
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发表时间：
2017-09
影响因子：
4.9
通讯作者：
Song EY
中科院分区：
文献类型：
--
作者：
Park H;Lee N;In JW;Roh EY;Park KU;Shin S;Yang J;Song EY
叉头框 P3 (Foxp3) 是调节性 T 细胞最可靠的标记物，在维持肾同种异体移植物耐受方面发挥着重要作用。最近，据报道，Foxp3 多态性与肾移植的移植结果相关。我们分析了 Foxp3 多态性与肾同种异体移植结果的关联。 Foxp3 多态性（rs3761548 A/C、rs2280883 C/T、rs5902434 del/ATT 和 rs2232365 A/G）通过 PCR 使用序列特异性引物 (PCR-SSP) 对 1996 年至 2004 年首尔国立大学医院的 231 名成年肾移植受者进行了测试。 rs3761548 CC 基因型的患者比 AC 或 AA 基因型的患者表现出更好的移植物存活率（对数秩检验，P=0.03）。 rs3761548 CC基因型患者的原发肾小球疾病复发率也低于AC或AA基因型患者（P=0.01）。 rs2280883 TT基因型患者的急性排斥反应（AR）频率低于rs2280883 CT或CC基因型患者（26.9% vs 53.3%，P=0.038）。 rs2280883 TT 基因型患者的移植物存活率也高于 CT 或 CC 基因型患者（P=0.03）。 Foxp3 rs3761548 CC 和 rs2280883 TT 基因型与肾移植的良好移植结果相关。需要涉及更多患者的进一步研究。
Forkhead box P3 (Foxp3) is the most reliable marker for regulatory T cells, which play an important role in maintaining renal allograft tolerance. Recently, Foxp3 polymorphisms have been reported to be associated with graft outcome in kidney transplantation. We analyzed the association of Foxp3 polymorphisms with renal allograft outcome. Foxp3 polymorphisms (rs3761548 A/C, rs2280883 C/T, rs5902434 del/ATT, and rs2232365 A/G) were tested by PCR with sequence-specific primers (PCR-SSP) in 231 adult kidney transplantation recipients from 1996-2004 at Seoul National University Hospital. Patients with the rs3761548 CC genotype showed better graft survival than those with the AC or AA genotype (log rank test, P=0.03). Patients with the rs3761548 CC genotype also showed a lower rate of recurrence of the original glomerular disease than those with the AC or AA genotype (P=0.01). The frequency of acute rejection (AR) in patients with the rs2280883 TT genotype was lower than that in patients with the rs2280883 CT or CC genotype (26.9% vs 53.3%, P=0.038). Patients with the rs2280883 TT genotype also showed better graft survival than those with the CT or CC genotype (P=0.03). Foxp3 rs3761548 CC and rs2280883 TT genotypes were associated with superior graft outcome of kidney transplantation. Further studies involving a larger number of patients are needed.
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影响因子：
2.3
作者：
Krepsova E;Tycova I;Sekerkova A;Wohlfahrt P;Hruba P;Striz I;Sawitzki B;Viklicky O
通讯作者：
Viklicky O
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通讯作者：
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6.7
作者：
Andre, Gustavo M.;Barbosa, Caio P.;Bianco, Bianca
通讯作者：
Bianco, Bianca
影响因子：
3.5
作者：
Owen, Catherine J.;Eden, James A.;Pearce, Simon H. S.
通讯作者：
Pearce, Simon H. S.
影响因子：
2.7
作者：
Engela, Anja U.;Boer, Karin;Baan, Carla C.
通讯作者：
Baan, Carla C.