Coordinating cerebral cortical construction and connectivity: Unifying influence of radial progenitors.
Coordinating cerebral cortical construction and connectivity: Unifying influence of radial progenitors.
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DOI：
10.1016/j.neuron.2022.01.034
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发表时间：
2022-04-06
期刊：
影响因子：
16.2
通讯作者：
Anton ES
中科院分区：
文献类型：
--
作者：
Casingal CR;Descant KD;Anton ES
放射状祖细胞的发育和功能为大脑皮层的构建奠定了基础。放射状神经胶质支架通过其作为神经源性祖细胞来源和神经元迁移引导的功能，被认为为大脑皮层的形成提供了模板。新出现的证据挑战了这种有限的观点。有趣的是，放射状神经胶质支架也可能在轴突生长、引导和神经元连接中发挥作用。放射状胶质细胞不仅促进皮层神经元的产生、放置和分配，而且还调节它们的连接方式。因此，放射状胶质细胞的组织和功能可能是发育中皮质的一个统一特征，有助于精确协调神经发生、神经元放置和连接的正确模式，这是出现功能性大脑皮层所必需的。这一视角批判性地探索了这一新兴观点及其在人脑发育和紊乱背景下的影响。放射状神经胶质前体细胞作为一种指导性基质，在发育中的大脑皮层中协调适当数量和类型的神经元的产生、定位和连接。在这里，Casingal等人在皮质发育和神经发育障碍的背景下探索了这一概念。
Radial progenitor development and function lay the foundation for the construction of the cerebral cortex. Radial glial scaffold, through its functions as a source of neurogenic progenitors and neuronal migration guide, is thought to provide a template for the formation of the cerebral cortex. Emerging evidence challenges this limited view. Intriguingly, radial glial scaffold may also play a role in axonal growth, guidance, and neuronal connectivity. Radial glial cells not only facilitate the generation, placement, and allocation of neurons in the cortex but also regulate how they wire up. The organization and function of radial glial cells may thus be a unifying feature of the developing cortex that helps to precisely coordinate the right patterns of neurogenesis, neuronal placement, and connectivity necessary for the emergence of a functional cerebral cortex. This perspective critically explores this emerging view and its impact in the context of human brain development and disorders. Radial glial progenitors serve as an instructive matrix to coordinate the generation, placement, and connectivity of appropriate numbers and types of neurons in the developing cerebral cortex. Here Casingal et al explore this concept in the context of cortical development and neurodevelopmental disorders.
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影响因子：
16.2
作者：
Cadwell, Cathryn R.;Bhaduri, Aparna;Mostajo-Radji, Mohammed A.;Keefe, Matthew G.;Nowakowski, Tomasz J.
通讯作者：
Nowakowski, Tomasz J.
DOI：
10.1146/annurev-cellbio-101512-122400
发表时间：
2013
影响因子：
11.3
作者：
Evsyukova I;Plestant C;Anton ES
通讯作者：
Anton ES
影响因子：
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作者：
Chau KF;Springel MW;Broadbelt KG;Park HY;Topal S;Lun MP;Mullan H;Maynard T;Steen H;LaMantia AS;Lehtinen MK
通讯作者：
Lehtinen MK
影响因子：
64.8
作者：
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--
影响因子：
25
作者：
Eze UC;Bhaduri A;Haeussler M;Nowakowski TJ;Kriegstein AR
通讯作者：
Kriegstein AR