Bacterial lifestyle shapes stringent response activation.
Bacterial lifestyle shapes stringent response activation.
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DOI:
10.1016/j.tim.2013.01.002
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发表时间:
2013-04
影响因子:
15.9
通讯作者:
Crosson, Sean
中科院分区:
文献类型:
--
作者:
Boutte, Cara C.;Crosson, Sean
Bacteria inhabit enormously diverse niches and have a correspondingly large array of regulatory mechanisms to adapt to often inhospitable and variable environments. The stringent response allows bacteria to quickly reprogram transcription in response to changes in nutrient availability. Although the proteins controlling this response are conserved in almost all bacterial species, recent work has illuminated considerable diversity in the starvation cues and regulatory mechanisms that activate stringent signaling proteins in bacteria from different environments. In this review we describe the signals and genetic circuitries that control the stringent signaling systems of a copiotroph, a bacteriovore, an oligotroph and a mammalian pathogen – Escherichia coli, Myxococcus xanthus, Caulobacter crescentus and Mycobacterium tuberculosis, respectively – and discuss how control of the stringent response in these species is adapted to their particular lifestyles.
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