Bacterial lifestyle shapes stringent response activation.

Bacterial lifestyle shapes stringent response activation.
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DOI:
10.1016/j.tim.2013.01.002
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发表时间:
2013-04
影响因子:
15.9
通讯作者:
Crosson, Sean
Crosson, Sean
中科院分区:
生物学1区
文献类型:
--
作者:
Boutte, Cara C.;Crosson, Sean

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细菌栖息在各种各样的生态位上,相应地有大量的调节机制来适应往往不适宜生存和变化的环境。严格的反应使细菌能够快速重新编程转录,以响应营养可用性的变化。尽管控制这种反应的蛋白质在几乎所有细菌物种中都是保守的,但最近的工作已经阐明了来自不同环境的细菌中激活严格信号蛋白的饥饿线索和调节机制的相当大的多样性。在这篇综述中,我们分别描述了控制共营养菌、嗜菌菌、寡营养菌和哺乳动物病原体(大肠杆菌、黄粘球菌、新月形杆菌和结核杆菌)严格信号系统的信号和遗传电路,并讨论了这些物种的严格反应控制是如何适应它们特定的生活方式的。
Bacteria inhabit enormously diverse niches and have a correspondingly large array of regulatory mechanisms to adapt to often inhospitable and variable environments. The stringent response allows bacteria to quickly reprogram transcription in response to changes in nutrient availability. Although the proteins controlling this response are conserved in almost all bacterial species, recent work has illuminated considerable diversity in the starvation cues and regulatory mechanisms that activate stringent signaling proteins in bacteria from different environments. In this review we describe the signals and genetic circuitries that control the stringent signaling systems of a copiotroph, a bacteriovore, an oligotroph and a mammalian pathogen – Escherichia coli, Myxococcus xanthus, Caulobacter crescentus and Mycobacterium tuberculosis, respectively – and discuss how control of the stringent response in these species is adapted to their particular lifestyles.
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