Plasmodium ovale curtisi and Plasmodium ovale wallikeri circulate simultaneously in African communities.
Plasmodium ovale curtisi and Plasmodium ovale wallikeri circulate simultaneously in African communities.
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DOI：
10.1016/j.ijpara.2011.01.004
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发表时间：
2011-05
影响因子：
4
通讯作者：
Sutherland CJ
中科院分区：
文献类型：
--
作者：
Oguike MC;Betson M;Burke M;Nolder D;Stothard JR;Kleinschmidt I;Proietti C;Bousema T;Ndounga M;Tanabe K;Ntege E;Culleton R;Sutherland CJ
我们提出两种相关的疟原虫引起卵形疟疾。在非洲的调查中，鉴别性PCR测试鉴定了这两个物种。③卵圆型库提氏疟原虫和卵圆型沃里克氏疟原虫在时间和空间上是同时发现的。它们之间缺乏重组并不是因为地理或时间上的分离。因此，物种屏障可以通过生物机制来维持。有人提出，人类的卵形疟疾是由两种密切相关但不同的疟疾寄生虫引起的，即卵形疟原虫（Plasmodium ovale curtisi）和卵形疟原虫（Plasmodium ovale wallikeri）。最近的研究表明，这两种寄生虫在国家一级是同域的。然而，仍然有可能在流行国家存在局部的地理，时间或生态障碍，阻止两个物种的基因组之间的重组。在此，使用专门设计用于区分P. o. curtisi和P.o. wallikeri，它表明，这两个物种是目前在刚果布拉柴维尔的诊所参加者，并同时发生在湖边和内陆地区在乌干达和比奥科岛，赤道几内亚。因此，P.o. curtisi和P.o.这些地方的瓦利克里在时间和空间上都完全同域。这些发现与生物屏障的存在相一致，而不是地理或生态因素，阻止了P.o.之间的重组。curtisi和P.o.沃里克里在乌干达和比奥科进行的横断面调查中，我们的结果表明，感染卵形疟原虫。比以前认为的更常见，在人口样本中发生的频率为1-6%，这两个拟议的物种在六个地点促成了卵形疟疾。非洲消灭疟疾方案需要包括控制P.o.的战略。curtisi和P.o.沃里克里
► We propose that two related species of malaria parasite cause ovale malaria. ► Discriminatory PCR tests identified both species in African surveys. ► Plasmodium ovale curtisi and Plasmodium ovale wallikeri were found together in time and space. ► Lack of recombination between them is not due to geographic or temporal separation. ► Therefore, the species barrier may be maintained by a biological mechanism(s). It has been proposed that ovale malaria in humans is caused by two closely related but distinct species of malaria parasite, Plasmodium ovale curtisi and Plasmodium ovale wallikeri. It was recently shown that these two parasite types are sympatric at the country level. However, it remains possible that localised geographic, temporal or ecological barriers exist within endemic countries which prevent recombination between the genomes of the two species. Here, using conventional and real-time quantitative PCR (qPCR) methods specifically designed to discriminate P. o. curtisi and P. o. wallikeri, it is shown that both species are present among clinic attendees in Congo-Brazzaville, and occur simultaneously both in lake-side and inland districts in Uganda and on Bioko Island, Equatorial Guinea. Thus P. o. curtisi and P. o. wallikeri in these localities are exactly sympatric in both time and space. These findings are consistent with the existence of a biological barrier, rather than geographical or ecological factors, preventing recombination between P. o. curtisi and P. o. wallikeri. In cross-sectional surveys carried out in Uganda and Bioko, our results show that infections with P. ovale spp. are more common than previously thought, occurring at a frequency of 1–6% in population samples, with both proposed species contributing to ovale malaria in six sites. Malaria elimination programmes in Africa need to include strategies for control of P. o. curtisi and P. o. wallikeri.
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影响因子：
2.1
作者：
LI, J;WIRTZ, RA;MCCUTCHAN, TF
通讯作者：
MCCUTCHAN, TF
影响因子：
2.7
作者：
Snounou, G;Pinheiro, L;do Rosario, VE
通讯作者：
do Rosario, VE
DOI：
10.1016/0035-9203(93)90274-t
发表时间：
1993-11-01
影响因子：
2.2
作者：
SNOUNOU, G;PINHEIRO, L;DOROSARIO, VE
通讯作者：
DOROSARIO, VE
影响因子：
9.4
作者：
Polley, Spencer D.;Mori, Yasuyoshi;Sutherland, Colin J.
通讯作者：
Sutherland, Colin J.
影响因子：
3
作者：
Culleton, Richard L.;Mita, Toshihiro;Tanabe, Kazuyuki
通讯作者：
Tanabe, Kazuyuki