Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health.
Significance and Diagnostic Role of Antimicrobial Cathelicidins (LL-37) Peptides in Oral Health.
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DOI：
10.3390/biom7040080
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发表时间：
2017-12-05
期刊：
影响因子：
5.5
通讯作者：
Khan E
中科院分区：
文献类型：
--
作者：
Khurshid Z;Naseem M;Yahya I Asiri F;Mali M;Sannam Khan R;Sahibzada HA;Zafar MS;Faraz Moin S;Khan E
Cathelicidins是一组在人体内发挥多种重要作用的口服抗菌肽，如其对口腔微生物的抗菌（广谱）作用，伤口愈合和血管生成，最近的证据表明其在癌症调节中的作用。Cathelicidins也存在于人类和其他哺乳动物中。通过与微环境的复杂相互作用，它导致促炎作用。已经进行了许多体外和体内实验，最终得出结论，这些独特的肽在先天免疫中发挥重要作用。肽以前体形式（防御素）释放，其在切割后导致凯萨林菌素形成。生活在主要关注非侵入性和纳米技术的时代，这最终导致唾液组学领域的进一步发展。基于当前的焦点创新，我们已经强调了生物化学，作用模式和cathelicidins在口腔中的重要性。
Cathelicidins are a group of oral antimicrobial peptides that play multiple vital roles in the human body, such as their antimicrobial (broad spectrum) role against oral microbes, wound healing, and angiogenesis, with recent evidences about their role in cancer regulation. Cathelicidins are present in humans and other mammals as well. By complex interactions with the microenvironment, it results in pro-inflammatory effects. Many in vitro and in vivo experiments have been conducted to ultimately conclude that these unique peptides play an essential role in innate immunity. Peptides are released in the precursor form (defensins), which after cleavage results in cathelicidins formation. Living in the era where the major focus is on non-invasive and nanotechnology, this ultimately leads to further advancements in the field of salivaomics. Based on current spotlight innovations, we have highlighted the biochemistry, mode of action, and the importance of cathelicidins in the oral cavity.
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影响因子：
3.4
作者：
Cheng Y;Prickett MD;Gutowska W;Kuo R;Belov K;Burt DW
通讯作者：
Burt DW
DOI：
10.1111/j.1432-1033.1996.0086n.x
发表时间：
1996-04-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
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Frohm, M;Gunne, H;Boman, HG
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Boman, HG
DOI：
10.1128/cdli.8.2.370-375.2001
发表时间：
2001-03-01
期刊：
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
影响因子：
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作者：
Bals, R;Lang, C;Wilson, JM
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Wilson, JM
影响因子：
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作者：
Barlow PG;Svoboda P;Mackellar A;Nash AA;York IA;Pohl J;Davidson DJ;Donis RO
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Donis RO
影响因子：
4.8
作者：
Gallo, RL;Kim, KJ;Gennaro, R
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