Oncological and functional outcome after transoral 532-nm pulsed potassium-titanyl-phosphate laser surgery for T1a glottic carcinoma
Oncological and functional outcome after transoral 532-nm pulsed potassium-titanyl-phosphate laser surgery for T1a glottic carcinoma
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经口 532 nm 脉冲磷酸钛氧钾激光手术治疗 T1a 声门癌后的肿瘤和功能结果
DOI：
10.1007/s10103-012-1121-4
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Yoshizaki T
中科院分区：
文献类型：
--
作者：
Murono S;Endo K;Kondo S;Wakisaka N;Yoshizaki T
T1 a声门癌经口激光手术（TLS）的主要问题是疾病控制和术后语音。本研究探讨了使用532 nm脉冲磷酸钛氧钾（KTP）激光作为传统二氧化碳（CO2）激光治疗T1 a声门癌的替代方案的TLS切除和消融策略的有效性。使用KTP激光切除肿瘤，然后使用KTP激光以非接触方式对手术边缘周围的粘膜进行环形消融。22/24例（91.7%）获得局部控制.语音相关生活质量问卷（V-RQOL）和语音障碍指数-10（VHI-10）的平均得分分别为81.0和6.2。V-RQOL评分与校正后的VHI-10评分之间存在高度显著相关性（r= 0.96）。采用KTP激光治疗早期声门癌的TLS获得了可接受的局部控制，术后语音与文献中报道的CO2激光相当，表明基于切除和消融策略的手术在肿瘤学和功能上可接受。
The major concerns related to transoral laser surgery (TLS) for T1a glottic carcinoma are disease control and postoperative voice. This study examines the efficacy of the excision and ablation strategy of TLS using the 532-nm pulsed potassium-titanyl-phosphate (KTP) laser as an alternative to the conventional carbon dioxide (CO2) laser in treating T1a glottis carcinoma. The tumor was excised using KTP laser, followed by circumferential ablation of the mucosa surrounding the surgical margin in a non-contact manner using the KTP laser. Local control was obtained in 22 of 24 patients (91.7 %). Mean scores on Voice-Related Quality of Life questionnaire (V-RQOL) and the Voice Handicap Index-10 (VHI-10) were 81.0 and 6.2, respectively. A highly significant correlation was observed between scores of V-RQOL and adjusted VHI-10 (r= 0.96). TLS with a KTP laser for early glottic carcinoma achieved acceptable local control and postoperative voice comparable to those with a CO2laser reported in the literature, suggesting that the procedure based on an excision and ablation strategy can be considered oncologically and functionally acceptable for this lesion.
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影响因子：
2.6
作者：
Remacle, M;Eckel, HE;Wustrow, TPU
通讯作者：
Wustrow, TPU
影响因子：
1.4
作者：
Cohen, Seth M.;Garrett, C. Gaelyn;Courey, Mark S.
通讯作者：
Courey, Mark S.
影响因子：
2.6
作者：
Burns, James A.;Zeitels, Steven M.;Anderson, Rox
通讯作者：
Anderson, Rox
影响因子：
2.6
作者：
Fung, K;Yoo, J;Venkatesan, VM
通讯作者：
Venkatesan, VM
DOI：
10.1002/hed.20500
发表时间：
2007-02-01
影响因子：
2.9
作者：
Goor, Kim M.;Peeters, A. Jeanne G. E.;van Agthoven, Michel
通讯作者：
van Agthoven, Michel